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A novel multistep method for chondroitin sulphate immobilization and its interaction with fibroblast cells

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dc.title A novel multistep method for chondroitin sulphate immobilization and its interaction with fibroblast cells en
dc.contributor.author Özaltin, Kadir
dc.contributor.author Lehocký, Marián
dc.contributor.author Kuceková, Zdenka
dc.contributor.author Humpolíček, Petr
dc.contributor.author Sáha, Petr
dc.relation.ispartof Materials Science and Engineering C
dc.identifier.issn 0928-4931 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2017
utb.relation.volume 70
dc.citation.spage 94
dc.citation.epage 100
dc.type article
dc.language.iso en
dc.publisher Elsevier Science B.V.
dc.identifier.doi 10.1016/j.msec.2016.08.065
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0928493116309808
dc.subject chondroitin sulphate en
dc.subject fibroblast en
dc.subject plasma treatment en
dc.subject Polyethylene en
dc.subject surface modification en
dc.description.abstract Polymeric biomaterials are widely used in medical applications owing to their low cost, processability and sufficient toughness. Surface modification by creating a thin film of bioactive agents is promising technique to enhance cellular interactions, regulate the protein adsorption and/or avoid bacterial infections. Polyethylene is one of the most used polymeric biomaterial but its hydrophobic nature impedes its further chemical modifications. Plasma treatment is unique method to increase its hydrophilicity by incorporating hydrophilic oxidative functional groups and tailoring the surface by physical etching. Furthermore, grafting of polymer brushes of amine group containing monomers onto the functionalized surface lead to strongly immobilized bioactive agents at the final step. Chondroitin sulphate is natural polysaccharide mainly found in connective cartilage tissue which used as a bioactive agent to immobilize onto polyethylene surface by multistep method in this study. © 2016 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006731
utb.identifier.rivid RIV/70883521:28610/17:63518166!RIV18-MSM-28610___
utb.identifier.obdid 43877933
utb.identifier.scopus 2-s2.0-84989851440
utb.identifier.wok 000388046900012
utb.identifier.pubmed 27770972
utb.source j-scopus
dc.date.accessioned 2016-12-22T16:18:59Z
dc.date.available 2016-12-22T16:18:59Z
dc.description.sponsorship LO1504, MŠMT, Ministry of Education, Youth and Sports
dc.description.sponsorship Operational Program Research and Development for Innovations; European Regional Development Fund (ERDF); national budget of Czech Republic [CZ.1.05/2.1.00/03.0111]; Ministry of Education, Youth and Sports of the Czech Republic [LO1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Özaltin, Kadir
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Kuceková, Zdenka
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.affiliation Kadir Ozaltin, Marián Lehocký ⁎ , Zdenka Kuceková, Petr Humpolíček, Petr Sáha Centre of Polymer Systems, Tomas Bata University in Zlín, Trida Tomase Bati 5678, 760 01 Zlín, Czech Republic ⁎ Corresponding author. E-mail address: lehocky@post.cz (M. Lehocký).
utb.fulltext.dates Received 27 June 2016 Received in revised form 22 August 2016 Accepted 24 August 2016 Available online 26 August 2016
utb.fulltext.sponsorship This work was co-funded by the Operational Program Research and Development for Innovations and by the European Regional Development Fund (ERDF) and national budget of Czech Republic, within the framework of project Centre of Polymer Systems (reg. number: CZ.1.05/2.1.00/03.0111). The authors would like to express their gratitude to the Ministry of Education, Youth and Sports of the Czech Repub- lic (Project no. LO1504).
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