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Polysaccharide-based nanocomplexes for co-encapsulation and controlled release of 5-Fluorouracil and Temozolomide

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dc.title Polysaccharide-based nanocomplexes for co-encapsulation and controlled release of 5-Fluorouracil and Temozolomide en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Pavelková, Alena
dc.contributor.author Maciulyte, Sandra
dc.contributor.author Budriene, Saulute
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof European Journal of Pharmaceutical Sciences
dc.identifier.issn 0928-0987 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 92
dc.citation.spage 276
dc.citation.epage 286
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.ejps.2016.05.001
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0928098716301555
dc.subject Alginic acid en
dc.subject Chitosan en
dc.subject Drug delivery en
dc.subject Polyelectrolytes en
dc.subject Polygalacturonic acid en
dc.description.abstract Polysaccharide-based nanocomplexes, intended for simultaneous encapsulation and controlled release of 5-Fluorouracil (5-FU) and Temozolomide (TMZ) were developed via the complexation method using chitosan, alginic and polygalacturonic acid. Investigation focused on the influence of polysaccharides on the properties of the system and amelioration of the stability of the drugs, in particular TMZ. The dimensions of particles and their ζ-potential were found to range between 100 and 200 nm and − 25 to + 40 mV, respectively. Encapsulation efficiency varied from 16% to over 70%, depending on the given system. The influence of pH on the release and co-release of TMZ and 5-FU was evaluated under different pH conditions. The stability of the loaded drug, in particular TMZ, after release was evaluated and confirmed by LC–MS analysis. Results suggested that the amount of loaded drug(s) and the release rate is connected with the weight ratio of polysaccharides and the pH of the media. One-way ANOVA analysis on the obtained data revealed no interference between the drugs during the encapsulation and release process, and in particular no hydrolysis of TMZ occurred suggesting that CS-ALG and CS-PGA would represent interesting carriers for multi-drug controlled release and drugs protection. © 2016 Elsevier B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006570
utb.identifier.obdid 43875211
utb.identifier.scopus 2-s2.0-84973099693
utb.identifier.wok 000381833900030
utb.identifier.pubmed 27154260
utb.identifier.coden EPSCE
utb.source j-scopus
dc.date.accessioned 2016-09-21T13:12:19Z
dc.date.available 2016-09-21T13:12:19Z
dc.description.sponsorship 15-08287Y, GACR, Czech Science Foundation
dc.description.sponsorship Czech Science Foundation [15-08287Y]; Ministry of Education, Youth and Sports of the Czech Republic [LO1504, LE12002]; Internal Grant Agency of TBU in Zlin [IGA/CPS/2016/004]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Pavelková, Alena
utb.contributor.internalauthor Sedlařík, Vladimír
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