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Enhanced biocompatibility of TiO2 surfaces by highly reactive plasma

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dc.title Enhanced biocompatibility of TiO2 surfaces by highly reactive plasma en
dc.contributor.author Junkar, Ita
dc.contributor.author Kulkarni, Mukta
dc.contributor.author Drašler, Barbara
dc.contributor.author Rugelj, Neža
dc.contributor.author Recek, Nina
dc.contributor.author Drobne, Damjana
dc.contributor.author Kövač, Janez
dc.contributor.author Humpolíček, Petr
dc.contributor.author Iglič, Aleš
dc.contributor.author Mozetič, Miran
dc.relation.ispartof Journal of Physics D: Applied Physics
dc.identifier.issn 0022-3727 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 49
utb.relation.issue 24
dc.type article
dc.language.iso en
dc.publisher Institute of Physics Publishing, Ltd. (IOP Publishing, Ltd.)
dc.identifier.doi 10.1088/0022-3727/49/24/244002
dc.relation.uri http://iopscience.iop.org/article/10.1088/0022-3727/49/24/244002/meta
dc.subject cells en
dc.subject implants en
dc.subject nanotubes en
dc.subject plasma treatment en
dc.subject surface modification en
dc.description.abstract In the present study the biological response to various nanotopographic features after gaseous plasma treatment were studied. The usefulness of nanostructured surfaces for implantable materials has already been acknowledged, while less is known on the combined effect of nanostructured plasma modified surfaces. In the present work the influence of oxygen plasma treatment on nanostructured titanium oxide (TiO2) surfaces was studied. Characterization of the TiO2 surface chemical composition and morphological features was analyzed after plasma modification by x-ray photoelectron spectroscopy and by scanning electron microscopy while surface wettability was studied with measuring the water contact angle. Cell adhesion and morphology was assessed from images taken with scanning electron microscopy, whereas cell viability was measured with a calorimetric assay. The obtained results showed that oxygen plasma treatment of TiO2 nanotube surfaces significantly influences the adhesion and morphology of osteoblast-like cells in comparison to untreated nanostructured surfaces. Marked changes in surface composition of plasma treated surfaces were observed, as plasma treatment removed hydrocarbon contamination and removed fluorine impurities, which were present due to the electrochemical anodization process. However no differences in wettability of untreated and plasma treated surfaces were noticed. Treatment with oxygen plasma stimulated osteoblast-like cell adhesion and spreading on the nanostructured surface, suggesting the possible use of oxygen plasma surface treatment to enhance osteoblast-like cell response. © 2016 IOP Publishing Ltd. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006379
utb.identifier.obdid 43875176
utb.identifier.scopus 2-s2.0-84971500213
utb.identifier.wok 000377427100006
utb.identifier.coden JPAPB
utb.source j-scopus
dc.date.accessioned 2016-07-26T14:58:22Z
dc.date.available 2016-07-26T14:58:22Z
dc.description.sponsorship Slovenian Research Agency (ARRS) [L7-7566]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Humpolíček, Petr
utb.fulltext.affiliation Ita Junkar 1, Mukta Kulkarni 2, Barbara Drašler 3, Neža Rugelj 3, Nina Recek 1, Damjana Drobne 3, Janez Kovač 1, Petr Humpolicek 4, Aleš Iglič 2, Miran Mozetič 1 1 Jožef Stefan Institute, Jamova Cesta 39, Ljubljana SI-1000, Slovenia 2 Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana SI-1000, Slovenia 3 Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia 4 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Nad Ovcirnou 3685, 760 01 Zlin, Czech Republic E-mail: Ita.junkar@ijs.si
utb.fulltext.dates Received 15 February 2016 revised 23 March 2016 Accepted for publication 15 April 2016 Published 12 May 2016
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
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