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Electrical activity of ferroelectric biomaterials and its effects on the adhesion, growth and enzymatic activity of human osteoblast-like cells

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dc.title Electrical activity of ferroelectric biomaterials and its effects on the adhesion, growth and enzymatic activity of human osteoblast-like cells en
dc.contributor.author Vaněk, Přemysl
dc.contributor.author Kolská, Zdeňka
dc.contributor.author Luxbacher, Thomas
dc.contributor.author López García, Jorge Andrés
dc.contributor.author Lehocký, Marián
dc.contributor.author Vandrovcová, Marta
dc.contributor.author Bačáková, Lucie
dc.contributor.author Petzelt, Jan
dc.relation.ispartof Journal of Physics D: Applied Physics
dc.identifier.issn 0022-3727 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 49
utb.relation.issue 17
dc.type article
dc.language.iso en
dc.publisher Institute of Physics Publishing
dc.identifier.doi 10.1088/0022-3727/49/17/175403
dc.relation.uri http://iopscience.iop.org/article/10.1088/0022-3727/49/17/175403/meta
dc.description.abstract Ferroelectrics have been, among others, studied as electroactive implant materials. Previous investigations have indicated that such implants induce improved bone formation. If a ferroelectric is immersed in a liquid, an electric double layer and a diffusion layer are formed at the interface. This is decisive for protein adsorption and bioactive behaviour, particularly for the adhesion and growth of cells. The charge distribution can be characterized, in a simplified way, by the zeta potential. We measured the zeta potential in dependence on the surface polarity on poled ferroelectric single crystalline LiNbO3 plates. Both our results and recent results of colloidal probe microscopy indicate that the charge distribution at the surface can be influenced by the surface polarity of ferroelectrics under certain 'ideal' conditions (low ionic strength, non-contaminated surface, very low roughness). However, suggested ferroelectric coatings on the surface of implants are far from ideal: they are rough, polycrystalline, and the body fluid is complex and has high ionic strength. In real cases, it can therefore be expected that there is rather low influence of the sign of the surface polarity on the electric diffusion layer and thus on the specific adsorption of proteins. This is supported by our results from studies of the adhesion, growth and the activity of alkaline phosphatase of human osteoblast-like Saos-2 cells on ferroelectric LiNbO3 plates in vitro. © 2016 IOP Publishing Ltd. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006284
utb.identifier.obdid 43874961
utb.identifier.scopus 2-s2.0-84963526822
utb.identifier.wok 000374146600025
utb.identifier.coden JPAPB
utb.source j-scopus
dc.date.accessioned 2016-06-22T12:14:39Z
dc.date.available 2016-06-22T12:14:39Z
dc.description.sponsorship 15-01558, GACR, Czech Science Foundation; MEYS, Czech Science Foundation
dc.description.sponsorship Czech Science Foundation [15-01558]; Ministry of Education, Youth and Sports of the Czech Republic [LO1504]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor López García, Jorge Andrés
utb.contributor.internalauthor Lehocký, Marián
utb.fulltext.affiliation P Vaněk 1, Z Kolská 2, T Luxbacher 3, J A L García 4, M Lehocký 4, M Vandrovcová 5, L Bačáková 5, J Petzelt 1 1 Institute of Physics of the Czech Academy of Sciences, Na Slovance 2, CZ-18221 Prague, Czech Republic 2 Faculty of Science, J. E. Purkyně University, České mládeže 8, CZ-40096 Ústí nad Labem, Czech Republic 3 Anton Paar GmbH, Anton Paar Str. 20, A-8054 Graz, Austria 4 Centre of Polymer Systems, Tomáš Baťa University in Zlín, nám T G Masaryka 5555, CZ-76001 Zlín, Czech Republic 5 Institute of Physiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague, Czech Republic E-mail: vanek@fzu.cz
utb.fulltext.dates Received 21 December 2015 revised 2 March 2016 Accepted for publication 11 March 2016 Published 1 April 2016
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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