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Water-insoluble thin films from palmitoyl hyaluronan with tunable properties

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dc.title Water-insoluble thin films from palmitoyl hyaluronan with tunable properties en
dc.contributor.author Foglarová, Marcela
dc.contributor.author Chmelař, Josef
dc.contributor.author Huerta-Angeles, Gloria
dc.contributor.author Vágnerová, Hana
dc.contributor.author Kulhánek, Jaromír
dc.contributor.author Bartoň Tománková, Kateřina
dc.contributor.author Minařík, Antonín
dc.contributor.author Velebný, Vladimír
dc.relation.ispartof Carbohydrate Polymers
dc.identifier.issn 0144-8617 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2016
utb.relation.volume 144
dc.citation.spage 68
dc.citation.epage 75
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.carbpol.2016.02.027
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0144861716300832
dc.subject Palmitoyl hyaluronan en
dc.subject Solution casting en
dc.subject Swelling en
dc.subject Tensile properties en
dc.subject Thin film en
dc.description.abstract Hyaluronan (HA) films exhibit properties suitable for various biomedical applications, but the solubility of HA limits their use in aqueous environments. Therefore, we developed water insoluble films based on palmitoyl esters of HA (pHA). Films were prepared from pHA samples with various degrees of substitution (DS) and molecular weights and their mechanical properties and swelling were characterized. Additionally, scanning electron microscopy and atomic force microscopy were used for visualization. Despite being prepared by solution casting, the films had a very smooth surface and were homogeneous in thickness. The film properties were in accordance with the polymer DS and molecular weight, enabling to tailor them for future applications by choosing a suitable pHA material. The behavior of the films toward cells was assessed in vitro. All films were non-cytotoxic and showed no adhesion of cells. These results show that the developed films are suitable candidates for various biomedical applications such as tissue engineering or wound healing. © 2016 Elsevier Ltd. All rights reserved. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1006277
utb.identifier.obdid 43874977
utb.identifier.scopus 2-s2.0-84961642744
utb.identifier.wok 000373830700009
utb.identifier.pubmed 27083794
utb.identifier.coden CAPOD
utb.source j-scopus
dc.date.accessioned 2016-06-22T12:14:38Z
dc.date.available 2016-06-22T12:14:38Z
dc.description.sponsorship NPUILO1304, MOE, Ministry of Education; NPUILO1504, MOE, Ministry of Education
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic [NPUILO1304, IGA LFUP_2015_008, NPUILO1504]; Operational Program Research and Development for Innovations - European Regional Development Fund (ERDF); National Budget of Czech Republic [CZ.1.05/2.1.00/03.0111]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Minařík, Antonín
utb.fulltext.affiliation Marcela Foglarová a∗, Josef Chmelař a, Gloria Huerta-Angeles b, Hana Vágnerová b, Jaromír Kulhánek b, Kateřina Bartoň Tománková c, Antonín Minařík d, Vladimír Velebný a a Contipro Biotech s.r.o., Dolní Dobrouč 401, Dolní Dobrouč 561 02, Czech Republic b Contipro Pharma a.s., Dolní Dobrouč 401, Dolní Dobrouč 561 02, Czech Republic c Department of Medical Biophysics, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University, Hněvotínská 3, Olomouc 775 15, Czech Republic d Centre of Polymer Systems, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, Zlín 760 01, Czech Republic ∗ Corresponding author. Tel.: +420 465 519 580; fax: +420 465 543 793. E-mail address: Marcela.Foglarova@contipro.com (M. Foglarová).
utb.fulltext.dates Received 25 November 2015 Received in revised form 1 February 2016 Accepted 8 February 2016 Available online 10 February 2016
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
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