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Chitosan grafted low molecular weight polylactic acid for protein encapsulation and burst effect reduction

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dc.title Chitosan grafted low molecular weight polylactic acid for protein encapsulation and burst effect reduction en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Kucharczyk, Pavel
dc.contributor.author Zedník, Jiří
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof International Journal of Pharmaceutics
dc.identifier.issn 0378-5173 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2015
utb.relation.volume 496
utb.relation.issue 2
dc.citation.spage 912
dc.citation.epage 921
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.ijpharm.2015.10.017
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0378517315302854
dc.subject Bovine serum albumin en
dc.subject Chitosan en
dc.subject Controlled drug delivery en
dc.subject Nanoparticles en
dc.subject Polylactic acid en
dc.description.abstract Chitosan and chitosan-grafted polylactic acid as a matrix for BSA encapsulation in a nanoparticle structure were prepared through a polyelectrolyte complexation method with dextran sulfate. Polylactic acid was synthetized via a polycondensation reaction using the non-metal-based initiator methanesulfonic acid and grafted to the chitosan backbone by a coupling reaction, with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide as the condensing agent. The effect of concentration of the polymer matrix utilized herein on particle diameter, ζ-potential, encapsulation efficiency, and the release kinetic of the model protein bovine serum albumin at differing pH levels was investigated. The influence of pH and ionic strength on the behavior of the nanoparticles prepared was also researched. Results showed that grafting polylactic acid to chitosan chains reduced the initial burst effect in the kinetics of BSA release from the structure of the nanoparticles. Furthermore, a rise in encapsulation efficiency of the bovine serum albumin and diminishment in nanoparticle diameter were observed due to chitosan modification. The results suggest that both polymers actually show appreciable encapsulation efficiency; and release rate of BSA. CS-g-PLA is more suitable than unmodified CS as a carrier for controlled protein delivery. © 2015 Elsevier B.V. All rights reserved. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1005784
utb.identifier.rivid RIV/70883521:28610/15:43874037!RIV16-MSM-28610___
utb.identifier.obdid 43874546
utb.identifier.scopus 2-s2.0-84949580204
utb.identifier.wok 000367384700077
utb.identifier.pubmed 26453778
utb.identifier.coden IJPHD
utb.source j-scopus
dc.date.accessioned 2016-04-12T11:51:56Z
dc.date.available 2016-04-12T11:51:56Z
dc.description.sponsorship Czech Science Foundation [15-08287Y]; Ministry of Education, Youth and Sports of the Czech Republic-Program NPU I [LO1504]; Internal Agency of Tomas Bata University in Zlin [IGA/CPS/2015/003]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Kucharczyk, Pavel
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Antonio Di Martino a, Pavel Kucharczyk a, Jiri Zednik b, Vladimir Sedlarik a* a Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr. T. Bati 5678, 760 01 Zlin, Czech Republic b Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030/8, Prague 2 128 43, Czech Republic
utb.fulltext.dates Received 10 June 2015 Received in revised form 2 October 2015 Accepted 3 October 2015 Available online 24 October 2015
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.faculty University Institute
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Centre of Polymer Systems
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