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Bacteriostatic activity of fluoroquinolone coatings on polyethylene films

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dc.title Bacteriostatic activity of fluoroquinolone coatings on polyethylene films en
dc.contributor.author Karbassi, Elika
dc.contributor.author Asadinezhad, Ahmad
dc.contributor.author Lehocký, Marián
dc.contributor.author Humpolíček, Petr
dc.contributor.author Sáha, Petr
dc.relation.ispartof Polymer Bulletin
dc.identifier.issn 0170-0839 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2015
utb.relation.volume 72
utb.relation.issue 8
dc.citation.spage 2049
dc.citation.epage 2058
dc.type article
dc.language.iso en
dc.publisher Springer
dc.identifier.doi 10.1007/s00289-015-1388-2
dc.relation.uri https://link.springer.com/article/10.1007/s00289-015-1388-2
dc.subject Low-density polyethylene en
dc.subject Fluoroquinolone en
dc.subject Antibacterial activity en
dc.subject Surface modification en
dc.subject Plasma treatment en
dc.description.abstract Low-density polyethylene films were surface modified through a three-step procedure to impart antibacterial property. Plasma treatment was followed by allylamine grafting to generate active functionalities on the surface. Three potent antibiotics including norfloxacin, ciprofloxacin and ofloxacin were then separately coated onto the surfaces. Each step of surface modification was well characterized in terms of chemical composition and bioactivity. It was found that the chemical structure of the antibiotic was highly determining in extent of antibiotic immobilization as well as in final biological performance of the modified substrates. An excellent activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial growth was observed for norfloxacin-coated substrate which corresponded to the highest amount of the antibiotic immobilized. However, almost no activity was seen for ofloxacin-coated surface. This was attributed to the ease of the antibiotic coating on the allylamine-grafted substrate where the lowest degree of coating was found for ofloxacin due to its unfavorable chemical structure. Gram-negative bacterial strain was found more vulnerable than Gram-positive strain which was explained on the basis of their different cell wall composition. The chemical structure of the antibiotic was found to be determining in amount of the material coated and also in level of the exhibited antibacterial activity. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1005277
utb.identifier.obdid 43873434
utb.identifier.scopus 2-s2.0-84938964059
utb.identifier.wok 000358413000014
utb.identifier.coden POBUD
utb.source j-wok
dc.date.accessioned 2015-08-28T12:05:00Z
dc.date.available 2015-08-28T12:05:00Z
dc.description.sponsorship Operational Program Research and Development for Innovations; European Regional Development Fund (ERDF); national budget of Czech Republic within the framework of project "Centre of Polymer Systems" [CZ.1.05./2.1.00/03.0111]; Grant Agency of Czech Republic [GA13-08944S]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Humpolíček, Petr
utb.contributor.internalauthor Sáha, Petr
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