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Minimální uzlinové postižení u karcinomu žaludku--pilotní výsledky multicentrické studie

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dc.title Minimální uzlinové postižení u karcinomu žaludku--pilotní výsledky multicentrické studie cs
dc.title Minimal node affection in gastric carcinoma--pilote multicentric study results en
dc.contributor.author Šimša, Jaromír
dc.contributor.author Hoch, Jiří
dc.contributor.author Leffler, Jan
dc.contributor.author Umlaufová, Dita
dc.contributor.author Schwarz, Jiří
dc.contributor.author Bělina, František
dc.contributor.author Ryska, Miroslav
dc.contributor.author Doležel, Radek
dc.contributor.author Gatěk, Jiří
dc.contributor.author Varga, Josef
dc.relation.ispartof Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
dc.identifier.issn 0035-9351 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2011
utb.relation.volume 90
utb.relation.issue 6
dc.citation.spage 333
dc.citation.epage 338
dc.type article
dc.language.iso cs
dc.relation.uri http://www.prolekare.cz/rozhledy-v-chirurgii-clanek/minimalni-uzlinove-postizeni-u-karcinomu-zaludku-pilotni-vysledky-multicentricke-studie-36191
dc.description.abstract Lymphadenectomy is an essential part of surgical treatment of gastric cancer. In the part of hematoxylin-eosin negative nodes, small foci of tumour cells (micrometastastasis and isolated tumour cells) can be found using immunostaing or RT-PCR. The aim of this study is to asses clinical and prognostic relevance of these findings. Multicenter, prospective, non-randomised clinical trial running in four Czech centres. All lymphatic nodes from patients after radical resection are stained using standard hematoxylin-eosin technique, all negative nodes are further processed with immunostaining employing cytokeratin antibody. In the period of two years (1st January 2009 - 31st December 2010), 73 patients (100%) were included into the study from four Czech centers. All patients underwent radical resection for gastric cancer. Subtotal resection was performed in 33 patients (45%), total gastrectomy in the remaining 40 patients (55%). Total number of acquired lymphatic nodes (LN) reached 1245, average number of nodes per one patient was 17.3. H-E metastasis were disclosed in 364 LN (29%). All H-E negative nodes were further processed using immunohistochemical staining. Lymph node micrometastasis (MM) were discovered in 35 LN (3%), isolated tumour cells (ITC) in another 72 LN (6%). Clinical and prognostic relevance of lymph node MM and ITC was assessed based on the patients' survival data. Preliminary results of this study indicate that presence of the lymph node MM and ITC in gastric cancer patients is not linked to worse oncological outcome. Based on our results we can conclude, that expensive, time consuming and technically demanding immunostaining technique could not yet be recommended as a routine part of histological investigation of lymphatic nodes. en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1005144
utb.identifier.rivid RIV/70883521:28150/11:43865669!RIV12-MSM-28150___
utb.identifier.obdid 43865685
utb.identifier.scopus 2-s2.0-84855176411
utb.identifier.pubmed 22026099
utb.source j-scopus
dc.date.accessioned 2015-06-29T11:54:09Z
dc.date.available 2015-06-29T11:54:09Z
utb.contributor.internalauthor Gatěk, Jiří
utb.fulltext.affiliation Šimša J., Hoch J.1, Leffler J.1, Umlaufová D.1, Schwarz J.1, Bělina F.2, Ryska M.2, Doležel R.2, Gatěk J.3, Varga J.4 Chirurgické oddělení Oblastní nemocnice Kolín, a.s., primář: doc. MUDr. Jaromír Šimša, Ph.D. 1 Chirurgická klinika 2. LF UK a FN Motol, Praha, přednosta: prof. MUDr. Jiří Hoch, CSc. 2 Chirurgická klinika 2. LF UK a UVN, Praha, přednosta: prof. MUDr. Miroslav Ryska, CSc. 3 Chirurgické oddělení Nemocnice Atlas Zlín, a.s., primář: MUDr. Jiří Gatěk, Ph.D. 4 Chirurgická klinika 1. LF UK a FN Bulovka, Praha, přednosta: doc. MUDr. Jan Fanta, CSc. Doc. MUDr. Jaromír Šimša, Ph.D. Musilova 317 149 00 Praha 4 e-mail: jaromir.simsa@nemocnicekolin.cz
utb.fulltext.dates -
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utb.fulltext.sponsorship Publikace vznikla za podpory grantu IGA 10550-3/2009.
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