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Effect of polylactide molecular weight on doxorubicin and temozolomide release from chitosan-grafted polylactide nanoparticles

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dc.title Effect of polylactide molecular weight on doxorubicin and temozolomide release from chitosan-grafted polylactide nanoparticles en
dc.contributor.author Di Martino, Antonio
dc.contributor.author Kucharczyk, Pavel
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof NANOCON 2013
dc.identifier.isbn 978-80-87294-47-5
dc.date.issued 2014
dc.citation.spage 521
dc.citation.epage 526
dc.event.title 5th NANOCON International Conference
dc.event.location Brno
utb.event.state-en Czech Republic
utb.event.state-cs Česká republika
dc.event.sdate 2013-10-16
dc.event.edate 2013-10-18
dc.type conferenceObject
dc.language.iso en
dc.publisher TANGER Ltd.
dc.relation.uri http://konsys-t.tanger.cz/files/proceedings/14/reports/2134.pdf
dc.subject chitosan en
dc.subject polylactide en
dc.subject doxorubicin en
dc.subject temozolomide en
dc.subject In vitro release en
dc.description.abstract The purpose of this study was to examine low molecular weight chitosan-grafted polylactide nanoparticles as a drug delivery system for doxorubicin and temozolomide. We investigated the effect of polylactide molecular weight on the release kinetic and encapsulation efficiency of both drugs. Polylactide (10 kDa and 60 kDa) has been linked to chitosan via coupling reaction. Chitosan-grafted-polylactide nanoparticles were prepared via ionotropic gelation method with tripolyphosphate as a linking agent. Results such as size (150-350 nm), zeta-potential (+25-35 mV), efficient encapsulation and prolonged release kinetic suggested that chitosan-grafted-poly lactic acid could be a great system for co-delivery of doxorubicin and temozolomide in Glioblastoma Multiforme treatment. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1004586
utb.identifier.obdid 43871264
utb.identifier.scopus 2-s2.0-84929417441
utb.identifier.wok 000352070900092
utb.source d-wok
dc.date.accessioned 2015-05-28T11:39:27Z
dc.date.available 2015-05-28T11:39:27Z
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Di Martino, Antonio
utb.contributor.internalauthor Kucharczyk, Pavel
utb.contributor.internalauthor Sedlařík, Vladimír
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