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Omission of adjuvant radiation therapy in elderly patients with low risk breast cancer undergoing breast-conserving surgery - two center experience

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dc.title Omission of adjuvant radiation therapy in elderly patients with low risk breast cancer undergoing breast-conserving surgery - two center experience en
dc.contributor.author Vrána, David
dc.contributor.author Gatěk, Jiří
dc.contributor.author Lukešová, Lucie
dc.contributor.author Vazan, Tomáš
dc.contributor.author Melichar, Bohuslav
dc.contributor.author Pospíšková, Markéta
dc.contributor.author Švach, Ivan
dc.relation.ispartof Biomedical Papers
dc.identifier.issn 1213-8118 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2014
utb.relation.volume 158
utb.relation.issue 3
dc.citation.spage 461
dc.citation.epage 464
dc.type article
dc.language.iso en
dc.publisher Univerzita Palackého v Olomouci
dc.identifier.doi 10.5507/bp.2013.032
dc.relation.uri http://biomed.papers.upol.cz/artkey/bio-201403-0021_Omission_of_adjuvant_radiation_therapy_in_elderly_patients_with_low_risk_breast_cancer_undergoing_breast-conser.php?back=%2Fsearch.php%3Fquery%3DOmission%2Bof%2Badjuvant%2Bradiation%2Btherapy%2Bin%2Belderly%2Bpatients%2Bwith%2Blow%2Brisk%2Bbreast%2Bcancer%2Bundergoing%2Bbreast-conserving%2Bsurgery%2B-%2Btwo%2Bcenter%2Bexperience%26sfrom%3D0%26spage%3D30#.VGYMV7FDghA
dc.subject Breast cancer en
dc.subject Elderly patients en
dc.subject Radiation-therapy en
dc.description.abstract Introduction. Breast cancer is, now often diagnosed in patients older than 70 years due to longer life expectancy. The usual treatment is mastectomy to obviate radiotherapy or breast-conserving surgery followed by radiotherapy. The aim of this study was to investigate the need for adjuvant radiotherapy in older patients and the consequences of omitting radiotherapy following conservative surgery.Methods. An extensive database search was made of patients who had been treated for breast cancer at the Department of Oncology, University Hospital Olomouc and the Atlas Hospital in Zlin (2004-2008). We identified 738 patients of whom 190 patients (25.7%) were older than 70 years of age. These were followed up for progression-free and overall survival. The cause of death was checked for breast cancer relapse.Results. In total only 9 patients undergoing breast saving surgery were ultimately identified. No patient had confirmed local recurrence during the follow up period: Two patients have died due to distant metastasis without local relapse and one patient has died for reasons other than breast cancer.Conclusion. Omitting radiotherapy after breast saving surgery provides an opportunity for women to undergo breast saving surgery and avoid 7 weeks of radiotherapy. This could significantly improve patient quality of life. In our of many years experience and from published randomized data, this procedure is safe for a select group of patients 70 years of age and older. en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1003867
utb.identifier.obdid 43872026
utb.identifier.scopus 2-s2.0-84907623909
utb.identifier.wok 000345398500021
utb.source j-scopus
dc.date.accessioned 2014-11-19T09:23:42Z
dc.date.available 2014-11-19T09:23:42Z
utb.contributor.internalauthor Gatěk, Jiří
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