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Purification of a conducting polymer, polyaniline, for biomedical applications

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dc.title Purification of a conducting polymer, polyaniline, for biomedical applications en
dc.contributor.author Stejskal, Jaroslav
dc.contributor.author Hajná, Milena
dc.contributor.author Kašpárková, Věra
dc.contributor.author Humpolíček, Petr
dc.contributor.author Zhigunov, Alexander
dc.contributor.author Trchová, Miroslava
dc.relation.ispartof Synthetic Metals
dc.identifier.issn 0379-6779 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2014
utb.relation.volume 195
dc.citation.spage 286
dc.citation.epage 293
dc.type article
dc.language.iso en
dc.publisher Elsevier
dc.identifier.doi 10.1016/j.synthmet.2014.06.020
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0379677914002252
dc.subject Biocompatibility en
dc.subject Conducting polymer en
dc.subject Polyaniline en
dc.subject Reprecipitation en
dc.subject Toxicity en
dc.description.abstract A conducting polymer, polyaniline, was prepared in globular and nanotubular morphologies. The protonated forms were converted to the corresponding bases and both types of samples were tested for cytotoxicity. The polyanilines were then suspended in N-methylpyrrolidone or in concentrated sulphuric acid, and the soluble parts were precipitated into methanol acidified with sulphuric acid. Such a dissolution/precipitation cycle was tested as a purification procedure for polyaniline, which would remove the potential low-molecular-weight components. The original morphology of polyaniline was destroyed in soluble part (18-24 wt.%) but maintained in the fraction insoluble in N-methylpyrrolidone. The fraction soluble in sulphuric acid was higher (56-64 wt.%). The original morphology converted to fragments after reprecipitation, and the samples became amorphous. The conductivity was reduced on average by two orders of magnitude. FTIR spectroscopy was used to assess the molecular structure, hydrogen bonding, and their changes. The cytotoxicity of polyaniline salt determined on mouse embryonic fibroblast cell line NIH/3T3 was reduced after reprecipitation from N-methylpyrrolidone when compared to the initial polymer and showed the absence of cytotoxicity at the extract concentration of 5 and 10% in the case of globular and nanotubular polymer, respectively. A corresponding positive effect was not observed for polyaniline reprecipitated from sulphuric acid. © 2014 Elsevier B.V. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1003839
utb.identifier.obdid 43872015
utb.identifier.scopus 2-s2.0-84904566283
utb.identifier.wok 000341469300040
utb.identifier.coden SYMED
utb.source j-scopus
dc.date.accessioned 2014-11-06T13:30:52Z
dc.date.available 2014-11-06T13:30:52Z
dc.description.sponsorship Czech Science Foundation [13-08944S]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Humpolíček, Petr
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