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Novel poly(lactic acid)-poly(ethylene oxide) chain-linked copolymer and its application in nano-encapsulation

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dc.title Novel poly(lactic acid)-poly(ethylene oxide) chain-linked copolymer and its application in nano-encapsulation en
dc.contributor.author Pavelková, Alena
dc.contributor.author Kucharczyk, Pavel
dc.contributor.author Stloukal, Petr
dc.contributor.author Koutný, Marek
dc.contributor.author Sedlařík, Vladimír
dc.relation.ispartof Polymers for Advanced Technologies
dc.identifier.issn 1042-7147 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2014
utb.relation.volume 25
utb.relation.issue 6
dc.citation.spage 595
dc.citation.epage 604
dc.type article
dc.language.iso en
dc.publisher Wiley-Blackwell
dc.identifier.doi 10.1002/pat.3241
dc.relation.uri http://onlinelibrary.wiley.com/doi/10.1002/pat.3241/abstract
dc.subject polylactide en
dc.subject chain-linking en
dc.subject diizocyanates en
dc.subject nanoparticles en
dc.subject encapsulation en
dc.description.abstract The work presented here investigates the synthesis of poly(lactic acid)-poly(ethylene oxide) diisocyanate chain-linked copolymer, and its application in the nano-encapsulation of bioactive compounds. Study was conducted on the effect of the type of chain-linking agent, along with molecular weight, thermal properties and hydrophilic/hydrophobic behavior, through the methods of gel permeation chromatography, Fourier transform infrared spectroscopy-attenuated total reflectance, differential scanning calorimetry, light scattering, water uptake experimentation, and water contact angle measurements. Nanoparticle formation was performed via a single solvent evaporation process, and the particles obtained were characterized by dynamic light scattering and scanning electron microscopy. Results show the significantly enhanced molecular weight of the final product after the chain-linking reaction (up to 300,000 g/mol), as well as the non-linear nature of the sample due to broad polydispersity, ranging from 4-13. The final products exhibited glass transition temperatures of between 30 and 44 degrees C, while their crystalline quality was either significantly suppressed or a completely amorphous attribute was observed. Nanoparticles in the range of 300 nm that contained metazachlor were successfully prepared, and their releasing behavior exhibited first order release kinetics. A slower rate of release was observed in samples containing 4,4'-methylenebis(phenyl isocyanate) as a chain-linker. Copyright (C) 2014 John Wiley & Sons, Ltd. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1003820
utb.identifier.obdid 43871789
utb.identifier.scopus 2-s2.0-84928773307
utb.identifier.wok 000337680300002
utb.source j-wok
dc.date.accessioned 2014-08-05T09:56:31Z
dc.date.available 2014-08-05T09:56:31Z
dc.description.sponsorship Operational Programme Research and Development for Innovations; European Regional Development Fund [CZ.1.05/2.1.00/03.0111]; Internal Grant Agency of Tomas Bata University in Zlin [IGA/FT/2013/004]; Grant Agency of Czech Republic [GACR P108/10/0200]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Pavelková, Alena
utb.contributor.internalauthor Kucharczyk, Pavel
utb.contributor.internalauthor Stloukal, Petr
utb.contributor.internalauthor Koutný, Marek
utb.contributor.internalauthor Sedlařík, Vladimír
utb.fulltext.affiliation Alena Pavelkova a,b, Pavel Kucharczyk a,b, Petr Stloukal b,c, Marek Koutny b,c and Vladimir Sedlarik a,b* * Correspondence to: Vladimir Sedlarik, Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, nam. T.G.Masaryka 275, 76272 Zlín, Czech Republic. E-mail: sedlarik@ft.utb.cz a A. Pavelkova, P. Kucharczyk, V. Sedlarik Polymer Centre, Faculty of Technology, Tomas Bata University in Zlin, nam. T. G.Masaryka 27576272 Zlín, Czech Republic b A. Pavelkova, P. Kucharczyk, P. Stloukal, M. Koutny, V. Sedlarik Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Nad Ovcirnou 3685760 01 Zlin, Czech Republic c P. Stloukal, M. Koutny Department of Environmental Protection Engineering, Faculty of Technology, Tomas Bata University in Zlin, nam. T.G.Masaryka 275762 72 Zlin, Czech Republic
utb.fulltext.dates -
utb.fulltext.sponsorship This work has been supported by Operational Programme Research and Development for Innovations, co-funded by the European Regional Development Fund (project CZ.1.05/2.1.00/03.0111). The authors are also grateful to the Internal Grant Agency of Tomas Bata University in Zlin (grant IGA/FT/2013/004) for co-funding. This work was also supported by the Grant Agency of Czech Republic (Grant GACR P108/10/0200).
utb.fulltext.projects CZ.1.05/2.1.00/03.0111
utb.fulltext.projects IGA/FT/2013/004
utb.fulltext.projects GACR P108/10/0200
utb.fulltext.faculty University Institute
utb.fulltext.faculty Faculty of Technology
utb.fulltext.faculty Faculty of Technology
utb.fulltext.ou Centre of Polymer Systems
utb.fulltext.ou Department of Environment Protection Engineering
utb.fulltext.ou Polymer Centre
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