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Hodnocení rychlosti glomerulární filtrace u diabetických pacientů

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dc.title Hodnocení rychlosti glomerulární filtrace u diabetických pacientů cs
dc.title Estimated glomerular filtration rate in diabetic patients en
dc.contributor.author Šálek, Tomáš
dc.contributor.author Ponížil, Petr
dc.relation.ispartof Klinická biochemie a metabolismus
dc.identifier.issn 1210-7921 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2014
utb.relation.volume 22
utb.relation.issue 1
dc.citation.spage 4
dc.citation.epage 7
dc.type article
dc.language.iso en
dc.publisher Česká lékařská společnost Jana Evangelisty Purkyně (ČLS JEP)
dc.relation.uri http://www.cskb.cz/cskb.php?pg=casopisy--kbm--2014
dc.subject Chronic kidney disease en
dc.subject Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) en
dc.subject Creatinine en
dc.subject Cystatin C en
dc.subject Glomerular filtration rate en
dc.description.abstract Objective: The aim of the study is to compare estimated glomerular filtration rate (eGFR) from serum creatinine (eGFRcreatinine) and cystatine C (eGFRcystatin C) and to study the impact of these estimations on detection and staging of chronic kidney disease (CKD) in diabetic patients. Design: retrospective cross section design. Settings: Department of clinical biochemistry, Tomas Bata Hospital Inc., Zlín, Czech Republic. Materials and methods: The study population consisted of 565 consecutive diabetic patients from the outpatient diabetic clinic of Tomas Bata Hospital in Zlin in the Czech Republic. Serum creatinine and cystatin C were measured by newly standardized methods and eGFR was calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, which were established in 2012. CKD is defined as GFR below 1.0 ml/s/1.73m2. Results: The mean eGFRcreatinine (1.443 ± 0.014) ml/s/1.73m2 was lower than eGFRcystatin C (1.512 ± 0.017) ml/s/1.73m 2, (p < 0.002). We found poor accordance to identify CKD. The discrepancy was found in 38 patients. Conclusion: Mean eGFRcystatin C was significantly higher than eGFRcreatinine. eGFR cystatin C gives higher values than eGFRcreatinine mainly at eGFR over 1.5 ml/s/1.73m2. Our results support the use of both eGFRcystatin C and eGFRcreatinine +cystatin C in patients with diabetes mellitus without albuminuria or another marker of kidney damage at GFR stages 2 and 3a according to eGFRcreatinine. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1003805
utb.identifier.obdid 43871798
utb.identifier.scopus 2-s2.0-84896080160
utb.identifier.coden KBMEF
utb.source j-scopus
dc.date.accessioned 2014-07-18T08:15:33Z
dc.date.available 2014-07-18T08:15:33Z
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Ponížil, Petr
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