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Significance of resection margin as a risk factor for local control of early stage breast cancer

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dc.title Significance of resection margin as a risk factor for local control of early stage breast cancer en
dc.contributor.author Gatěk, Jiří
dc.contributor.author Vrána, David
dc.contributor.author Lukešová, Lucie
dc.contributor.author Pospíšková, Markéta
dc.contributor.author Vážan, Petr
dc.contributor.author Melichar, Bohuslav
dc.relation.ispartof Biomedical Papers
dc.identifier.issn 1213-8118 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2013
utb.relation.volume 157
utb.relation.issue 3
dc.citation.spage 209
dc.citation.epage 213
dc.type article
dc.language.iso en
dc.publisher Univerzita Palackého v Olomouci cs
dc.identifier.doi 10.5507/bp.2013.067
dc.relation.uri http://biomed.papers.upol.cz/artkey/bio-201303-0001_Significance_of_resection_margin_as_a_risk_factor_for_local_control_of_early_stage_breast_cancer.php#.Upc38-QaLwM
dc.subject Breast cancer en
dc.subject Local relapse en
dc.subject Resection margin en
dc.description.abstract Breast conserving surgery combined with sentinel node biopsy represents currently the gold standard of treatment for early breast cancer. Although breast conserving surgery has been a widely accepted method for many years, there remain some highly controversial unresolved issues. The present analysis focused on the resection margin as one of the key factors for local control of the disease. Methods. Patient disease free survival and overall survival were collected from patients undergoing breast conserving surgery from 2004 to 2009 at the Department of Surgery Atlas hospital Zlin, Czech Republic. All patients with resection margin less then 5 mm were re-resected to achieve this clear resection margin of 5mm or more. Disease free survival (more specifically local relapse free survival, metastasis free survival and regional free survival) and overall survival were assessed. Results. The data on 330 patients were analyzed and 286/330 cases had complete follow-up. After a median follow-up of 70 months, 7 patients with isolated local relapse were identified (2.44%), 13 patients with distant metastasis without local relapse (4.54%) and 2 patients with relapse in the axilla without local relapse in the breast (0.7%). Conclusion. The final decision about the extent of resection margin remains controversial but based on the data on local control presented here it seems reasonable to increase the criteria for a clear resection margin to 5 mm. en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1003540
utb.identifier.obdid 43870073
utb.identifier.scopus 2-s2.0-84887270387
utb.identifier.wok 000329091100002
utb.source j-scopus
dc.date.accessioned 2013-11-29T09:48:54Z
dc.date.available 2013-11-29T09:48:54Z
utb.contributor.internalauthor Gatěk, Jiří
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