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Sentinel node biopsy and neoadjuvant chemotherapy in the treatment of breast cancer

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dc.title Sentinel node biopsy and neoadjuvant chemotherapy in the treatment of breast cancer en
dc.contributor.author Gatěk, Jiří
dc.contributor.author Vrána, David
dc.contributor.author Hnátek, Lukáš
dc.contributor.author Bakala, Jiří
dc.contributor.author Dudešek, Bohumil
dc.contributor.author Duben, Jiří
dc.contributor.author Musil, Tomáš
dc.relation.ispartof Journal of B.U.ON.
dc.identifier.issn 1107-0625 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2012
utb.relation.volume 17
utb.relation.issue 2
dc.citation.spage 265
dc.citation.epage 270
dc.type article
dc.language.iso en
dc.publisher Zerbinis Medical Publications en
dc.subject Breast cancer en
dc.subject Chemotherapy en
dc.subject Sentinel lymph node en
dc.description.abstract Purpose: Sentinel lymph node biopsy (SLNB) has become a safe and accurate alternative to axillary lymph node dissection (ALND) in the surgical management of early breast cancer. The aim of this study was to determine the false negative rate of SLNB in patients with advanced breast cancer after neoadjuvant chemotherapy. Methods: Forty-eight patients with 49 advanced breast cancers (one patient had bilateral disease) underwent neoadjuvant chemotherapy. All of them had SLNB, followed by standard level I/II ALND. SLNs were identified in 47 out of 49 tumors (detection rate 95.9%). Results: Axillary nodal metastases were detected in 28 patients; SLNs were positive only in 14 patients. Four sentinel internal mammary nodes were removed in 4 patients, while one of them was positive with micrometastasis but axillary nodes were negative. False-negative results occurred in 2 (7.14%) patients. The results of our study confirm that SLNB in patients with advanced breast cancer is not significantly altered by the preoperative chemotherapy. Biopsy results were very similar to those without any neoadjuvant chemotherapy. Conclusion: ALND, known for its serious complications, can be replaced in some cases by SLNB. © 2012 Zerbinis Medical Publications. en
utb.faculty Faculty of Humanities
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1002907
utb.identifier.rivid RIV/70883521:28150/12:43867922!RIV13-MSM-28150___
utb.identifier.rivid RIV/70883521:28610/12:43867922!RIV13-MSM-28610___
utb.identifier.obdid 43868013
utb.identifier.scopus 2-s2.0-84863630146
utb.identifier.wok 000306163900009
utb.identifier.coden JBUOF
utb.source j-scopus
dc.date.accessioned 2012-07-31T10:35:37Z
dc.date.available 2012-07-31T10:35:37Z
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Gatěk, Jiří
utb.contributor.internalauthor Hnátek, Lukáš
utb.contributor.internalauthor Musil, Tomáš
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