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A physicochemical approach to render antibacterial surfaces on plasma-treated medical-grade PVC: Irgasan coating

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dc.title A physicochemical approach to render antibacterial surfaces on plasma-treated medical-grade PVC: Irgasan coating en
dc.contributor.author Asadinezhad, Ahmad
dc.contributor.author Novák, Igor
dc.contributor.author Lehocký, Marián
dc.contributor.author Sedlařík, Vladimír
dc.contributor.author Vesel, Alenka
dc.contributor.author Junkar, Ita
dc.contributor.author Sáha, Petr
dc.contributor.author Chodák, Ivan
dc.relation.ispartof Plasma Processes and Polymers
dc.identifier.issn 1612-8850 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2010
utb.relation.volume 7
utb.relation.issue 6
dc.citation.spage 504
dc.citation.epage 514
dc.type article
dc.language.iso en
dc.publisher Wiley-VCH Verlag GmbH & Co. en
dc.identifier.doi 10.1002/ppap.200900132
dc.relation.uri http://onlinelibrary.wiley.com/doi/10.1002/ppap.200900132/full
dc.subject antibacterial coatings en
dc.subject irgasan en
dc.subject surface modification en
dc.subject triclosan en
dc.subject poly(vinyl chloride) (pvc) en
dc.subject bacterial adhesion en
dc.subject glow-discharge en
dc.subject polymer surfaces en
dc.subject nitrogen-plasma en
dc.subject acrylic-acid en
dc.subject oxygen en
dc.subject films en
dc.subject polyethylene en
dc.description.abstract A multistep physicochemical approach was adopted to develop a novel surface active antibacterial medical-grade polyvinyl chloride (PVC). This was accomplished through surface activation via diffuse coplanar surface barrier discharge plasma in air at ambient temperature and pressure, followed by radical graft copolymerization of acrylic acid onto the surface via grafting-from pathway to yield a well-defined high density brush. Irgasan as a potent biocide was then coated onto the functionalized surface to impart antimicrobial properties. Contact angle measurements showed an improved hydrophilicity upon multistep modifications. Alterations in surface free energy values were tracked through various known models. The equilibrium water absorption test corroborated the contact angle analysis. Scanning electron microscopy revealed etched features on the plasma treated sample as well as a brush-like pattern on the graft copolymerized surface. Surface chemistry was explored by Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and X-ray Photoelectron Spectroscopy (XPS), which confirmed the presence of irgasan non-covalently anchored onto the surface. An excellent bacteriostatic performance was exhibited by the irgasan coated sample using the agar diffusion test method against two potentially pathogenic gram-negative and particularly gram-positive bacterial strains implying a facile release of the antibacterial agent. However, in vitro bacterial adhesion and biofilm formation assays indicated incapability of irgasan in hindering the adherence after 24 h incubation. Nevertheless, the plasma treated and graft copolymerized samples were appreciably effective to diminish the adherence of gram-negative strain. Wettability and surface configuration of the substrate, besides bacteria structural characteristics, were established to be crucial factors in the adhesion phenomenon. The irgasan coated medical-grade PVC was suggested to be suited for use in disposable medical catheters of dependable antimicrobial performance. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1001712
utb.identifier.rivid RIV/70883521:28610/10:63509219!RIV11-MPO-28610___
utb.identifier.obdid 43864571
utb.identifier.scopus 2-s2.0-77954911077
utb.identifier.wok 000279494500008
utb.source j-riv
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Asadinezhad, Ahmad
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Sedlařík, Vladimír
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.affiliation Ahmad Asadinezhad, Igor Novák, Marián Lehocký,* Vladimír Sedlařík, Alenka Vesel, Ita Junkar, Petr Sáha, Ivan Chodák
utb.fulltext.dates Received: August 15, 2009 Revised: November 22, 2009 Accepted: November 24, 2009
utb.fulltext.sponsorship The authors express their gratitude for financing this research to the Ministry of Education, Youth, and *■ Sports of the Czech Republic (Grant VZ MSM 7088352101) as well as (Grant MPO 2A-1TP1/126), the Slovak Academy of Sciences (Grant VEGA 2/7103/27), and the Slovenia Ministry of Higher Education, Science, and Technology (Program P2-0082-2, Thin Film Structures
utb.fulltext.projects MSM 7088352101
utb.fulltext.projects VEGA 2/7103/27
utb.fulltext.projects MPO 2A-1TP1/126
utb.fulltext.faculty -
utb.fulltext.ou -
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