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Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins

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dc.title Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins en
dc.contributor.author Horna, Aleš
dc.contributor.author Nováková, Lucie
dc.contributor.author Lopéz, Sofía Arnal
dc.contributor.author Solichová, Dagmar
dc.contributor.author Šatínský, Dalibor
dc.contributor.author Kulichová, Bohumila
dc.contributor.author Solich, Petr
dc.relation.ispartof Talanta
dc.identifier.issn 0039-9140 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2009
utb.relation.volume 78
utb.relation.issue 3
dc.citation.spage 834
dc.citation.epage 839
dc.type article
dc.language.iso en
dc.publisher Elsevier Science B.V. en
dc.identifier.doi 10.1016/j.talanta.2008.12.057
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0039914009000058
dc.subject Atorvastatin en
dc.subject Lovastatin en
dc.subject Simvastatin en
dc.subject HPLC en
dc.subject CAD en
dc.subject Pharmaceutical analysis en
dc.description.abstract CAD (charged aerosol detector) has recently become a new alternative detection system in HPLC. This detection approach was applied in a new HPLC method for the determination of three of the major statins used in clinical treatment?simvastatin, lovastatin and atorvastatin. The method was optimized and the influence of individual parameters on CAD response and sensitivity was carefully studied. Chromatography was performed on a Zorbax Eclipse XDB C18 (4.6 mm × 75 mm, 3.5 ?m), using acetonitrile and formic acid 0.1% as mobile phase. The detection was performed using both CAD (20 pA range) and DAD (diode array detector?238 nm) simultaneously connected in series. In terms of linearity, precision and accuracy, the method was validated using tablets containing atorvastatin and simvastatin. The CAD is designated to be a non-linear detector in a wide dynamic range, however, in this application and in the tested concentration range its response was found to be perfectly linear. The limits of quantitation (0.1 ?g/ml) were found to be two times lower than those of UV detection. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1001703
utb.identifier.rivid RIV/70883521:28610/09:63508007!RIV10-MSM-28610___
utb.identifier.obdid 43861801
utb.identifier.scopus 2-s2.0-61449157658
utb.identifier.wok 000264976600032
utb.source j-riv
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Horna, Aleš
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