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Study of interactions between metallothionein and cisplatin by using differential pulse voltammetry Brdicka's reaction and quartz crystal microbalance

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dc.title Study of interactions between metallothionein and cisplatin by using differential pulse voltammetry Brdicka's reaction and quartz crystal microbalance en
dc.contributor.author Húska, Dalibor
dc.contributor.author Fabrik, Ivo
dc.contributor.author Baloun, Jiří
dc.contributor.author Adam, Vojtěch
dc.contributor.author Masařík, Michal
dc.contributor.author Hubálek, Jaromír
dc.contributor.author Vašků, Anna
dc.contributor.author Trnková, Libuše
dc.contributor.author Horna, Aleš
dc.contributor.author Zeman, Ladislav
dc.contributor.author Kizek, René
dc.relation.ispartof Sensors
dc.identifier.issn 1424-8220 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2009
utb.relation.volume 9
utb.relation.issue 3
dc.citation.spage 1355
dc.citation.epage 1369
dc.type article
dc.language.iso en
dc.publisher Molecular Diversity Preservation International (MDPI) en
dc.identifier.doi 10.3390/s90301355
dc.relation.uri http://www.mdpi.com/1424-8220/9/3/1355/
dc.subject Cancer en
dc.subject Metallothionein en
dc.subject Cisplatin en
dc.subject Protein-Drug Interaction en
dc.subject Voltammetry en
dc.subject Brdicka's reaction en
dc.subject Quartz Crystal Microbalance en
dc.description.abstract Treatment strategies for tumour diseases are progressively focusing on personalization of medicine. However, this focus requires methods revealing the early general biological mechanisms, including the formation anti-cancer drugs' resistance. The low molecular mass protein metallothionein is thought to be the crucial for the formation of resistance in tumour treatment based on the platinum-cytostatics. The interactions between metallothionein (MT) and cisplatin were determined by the adsorptive transfer stripping technique coupled with the differential pulse votlammetry Brdicka's reaction. The signals related to the MT-cisplatin complex appeared at -0.9 V. The formation of this complex depended on the time of interaction between cisplatin and MT. The complex formation was consequently confirmed by quartz crystal microbalance analyses. The formation of this complex was detectable even after a 20 s long interaction. Moreover, we detected presence of MT-cisplatin complex in the blood of male rats treated with this drug. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1001701
utb.identifier.rivid RIV/70883521:28610/09:63508005!RIV10-MSM-28610___
utb.identifier.obdid 43861799
utb.identifier.scopus 2-s2.0-63849152754
utb.identifier.wok 000264572700005
utb.source j-riv
dc.rights Attribution 3.0 International
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Horna, Aleš
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Attribution 3.0 International Except where otherwise noted, this item's license is described as Attribution 3.0 International