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Bacterial cellulose/graphene oxide/hydroxyapatite biocomposite: A scaffold from sustainable sources for bone tissue engineering

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dc.title Bacterial cellulose/graphene oxide/hydroxyapatite biocomposite: A scaffold from sustainable sources for bone tissue engineering en
dc.contributor.author Challa, Adam Aberra
dc.contributor.author Saha, Nabanita
dc.contributor.author Zhivkova, Tanya
dc.contributor.author Alexandrova, Radostina
dc.contributor.author Sáha, Petr
dc.relation.ispartof ACS Applied Materials and Interfaces
dc.identifier.issn 1944-8244 Scopus Sources, Sherpa/RoMEO, JCR
dc.identifier.issn 1944-8252 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2025
utb.relation.volume 17
utb.relation.issue 1
dc.citation.spage 572
dc.citation.epage 582
dc.type article
dc.language.iso en
dc.publisher American Chemical Society
dc.identifier.doi 10.1021/acsami.4c17306
dc.relation.uri https://pubs.acs.org/doi/10.1021/acsami.4c17306
dc.subject bacterial cellulose en
dc.subject nanofibrous network en
dc.subject biocomposite en
dc.subject scaffold en
dc.subject sustainable biomaterial en
dc.subject bone tissueengineering en
dc.description.abstract Bone tissue engineering demands advanced biomaterials with tailored properties. In this regard, composite scaffolds offer a strategy to integrate the desired functionalities. These scaffolds are expected to provide sufficient cellular activities while maintaining the required strength necessary for the bone repair for which they are intended. Hence, attempts to obtain efficient composites are growing. However, in most cases, the conventional production methods of scaffolds are energy-intensive and leave an impact on the environment. This work aims to develop a biocomposite scaffold integrating bacterial cellulose (BC), hydroxyapatite (HAp), and graphene oxide (GO), designated as “BC/HAp/GO”. All components are sourced primarily from agricultural and food waste as alternative means. BC, known for its biocompatibility, fine fiber network, and high porosity, serves as an ideal scaffold material. HAp, a naturally occurring bone component, contributes osteoconductive properties, while GO provides mechanical strength and biofunctionalization capabilities. The biomaterials were analyzed and characterized using a scanning electron microscope, a X-ray diffractometer, and a Fourier transform infrared spectrometer. The produced biocomposite scaffolds were tested for thermal stability, mechanical strength, and biocompatibility. The results showed a nanofibrous, porous network of BC, highly crystalline HAp particles, and well-oxygenated GO flakes with slight structural deformities. The synthesized biocomposite demonstrated promising characteristics, such as increased tensile strength due to added GO particles and higher bioactivity through the introduction of HAp. These inexpensively synthesized materials, marked by suitable surface morphology and cell adhesion properties, open potential applications in bone repair and regeneration. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1012275
utb.identifier.scopus 2-s2.0-85212658559
utb.identifier.wok 001380415600001
utb.identifier.pubmed 39698804
utb.source j-scopus
dc.date.accessioned 2025-01-30T10:36:18Z
dc.date.available 2025-01-30T10:36:18Z
dc.description.sponsorship Tomas Bata University in Zlín, TBU; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT, (RP/CPS/2024-28/005, IGA/CPS/2023/005, IGA/CPS/2024/005); Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT
dc.description.sponsorship Tomas Bata University in Zl?n [RP/CPS/2024-28/005]; Ministry of Education, Youth and Sports of the Czech Republic [IGA/CPS/2023/005, IGA/CPS/2024/005]; Internal Grant Agency (IGA) project; Center of Polymer Systems at the Tomas Bata University in Zlin, Czech Republic [MSMT-44726/2013]; Ministry of Education, Youth, and Sports
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Challa, Adam Aberra
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Sáha, Petr
utb.fulltext.sponsorship This study was supported by the Ministry of Education, Youth and Sports of the Czech Republic, under DKRVO (RP/CPS/2024-28/005), as well as through partial financial contributions from the Internal Grant Agency (IGA) project, Nos. IGA/CPS/2023/005 and IGA/CPS/2024/005, of the Center of Polymer Systems at the Tomas Bata University in Zlin, Czech Republic. A.A.C. is also pleased to acknowledge the Ministry of Education, Youth, and Sports support for foreign nationals under Reference MSMT-44726/2013.
utb.wos.affiliation [Challa, Adam Aberra; Saha, Nabanita; Saha, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Zhivkova, Tanya; Alexandrova, Radostina] Bulgarian Acad Sci, Inst Expt Morphol Pathol & Anthropol Museum, Sofia 1113, Bulgaria
utb.scopus.affiliation Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, třída Tomáše Bati 5678, Zlín, 76001, Czech Republic; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 25, Sofia, 1113, Bulgaria
utb.fulltext.projects RP/CPS/2024-28/005
utb.fulltext.projects IGA/CPS/2023/005
utb.fulltext.projects IGA/CPS/2024/005
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Attribution 4.0 International Kromě případů, kde je uvedeno jinak, licence tohoto záznamu je Attribution 4.0 International