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dc.title | Bacterial cellulose/graphene oxide/hydroxyapatite biocomposite: A scaffold from sustainable sources for bone tissue engineering | en |
dc.contributor.author | Challa, Adam Aberra | |
dc.contributor.author | Saha, Nabanita | |
dc.contributor.author | Zhivkova, Tanya | |
dc.contributor.author | Alexandrova, Radostina | |
dc.contributor.author | Sáha, Petr | |
dc.relation.ispartof | ACS Applied Materials and Interfaces | |
dc.identifier.issn | 1944-8244 Scopus Sources, Sherpa/RoMEO, JCR | |
dc.identifier.issn | 1944-8252 Scopus Sources, Sherpa/RoMEO, JCR | |
dc.date.issued | 2025 | |
utb.relation.volume | 17 | |
utb.relation.issue | 1 | |
dc.citation.spage | 572 | |
dc.citation.epage | 582 | |
dc.type | article | |
dc.language.iso | en | |
dc.publisher | American Chemical Society | |
dc.identifier.doi | 10.1021/acsami.4c17306 | |
dc.relation.uri | https://pubs.acs.org/doi/10.1021/acsami.4c17306 | |
dc.subject | bacterial cellulose | en |
dc.subject | nanofibrous network | en |
dc.subject | biocomposite | en |
dc.subject | scaffold | en |
dc.subject | sustainable biomaterial | en |
dc.subject | bone tissueengineering | en |
dc.description.abstract | Bone tissue engineering demands advanced biomaterials with tailored properties. In this regard, composite scaffolds offer a strategy to integrate the desired functionalities. These scaffolds are expected to provide sufficient cellular activities while maintaining the required strength necessary for the bone repair for which they are intended. Hence, attempts to obtain efficient composites are growing. However, in most cases, the conventional production methods of scaffolds are energy-intensive and leave an impact on the environment. This work aims to develop a biocomposite scaffold integrating bacterial cellulose (BC), hydroxyapatite (HAp), and graphene oxide (GO), designated as “BC/HAp/GO”. All components are sourced primarily from agricultural and food waste as alternative means. BC, known for its biocompatibility, fine fiber network, and high porosity, serves as an ideal scaffold material. HAp, a naturally occurring bone component, contributes osteoconductive properties, while GO provides mechanical strength and biofunctionalization capabilities. The biomaterials were analyzed and characterized using a scanning electron microscope, a X-ray diffractometer, and a Fourier transform infrared spectrometer. The produced biocomposite scaffolds were tested for thermal stability, mechanical strength, and biocompatibility. The results showed a nanofibrous, porous network of BC, highly crystalline HAp particles, and well-oxygenated GO flakes with slight structural deformities. The synthesized biocomposite demonstrated promising characteristics, such as increased tensile strength due to added GO particles and higher bioactivity through the introduction of HAp. These inexpensively synthesized materials, marked by suitable surface morphology and cell adhesion properties, open potential applications in bone repair and regeneration. | en |
utb.faculty | University Institute | |
dc.identifier.uri | http://hdl.handle.net/10563/1012275 | |
utb.identifier.scopus | 2-s2.0-85212658559 | |
utb.identifier.wok | 001380415600001 | |
utb.identifier.pubmed | 39698804 | |
utb.source | j-scopus | |
dc.date.accessioned | 2025-01-30T10:36:18Z | |
dc.date.available | 2025-01-30T10:36:18Z | |
dc.description.sponsorship | Tomas Bata University in Zlín, TBU; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT, (RP/CPS/2024-28/005, IGA/CPS/2023/005, IGA/CPS/2024/005); Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT | |
dc.description.sponsorship | Tomas Bata University in Zl?n [RP/CPS/2024-28/005]; Ministry of Education, Youth and Sports of the Czech Republic [IGA/CPS/2023/005, IGA/CPS/2024/005]; Internal Grant Agency (IGA) project; Center of Polymer Systems at the Tomas Bata University in Zlin, Czech Republic [MSMT-44726/2013]; Ministry of Education, Youth, and Sports | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.rights.access | openAccess | |
utb.ou | Centre of Polymer Systems | |
utb.contributor.internalauthor | Challa, Adam Aberra | |
utb.contributor.internalauthor | Saha, Nabanita | |
utb.contributor.internalauthor | Sáha, Petr | |
utb.fulltext.sponsorship | This study was supported by the Ministry of Education, Youth and Sports of the Czech Republic, under DKRVO (RP/CPS/2024-28/005), as well as through partial financial contributions from the Internal Grant Agency (IGA) project, Nos. IGA/CPS/2023/005 and IGA/CPS/2024/005, of the Center of Polymer Systems at the Tomas Bata University in Zlin, Czech Republic. A.A.C. is also pleased to acknowledge the Ministry of Education, Youth, and Sports support for foreign nationals under Reference MSMT-44726/2013. | |
utb.wos.affiliation | [Challa, Adam Aberra; Saha, Nabanita; Saha, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Zhivkova, Tanya; Alexandrova, Radostina] Bulgarian Acad Sci, Inst Expt Morphol Pathol & Anthropol Museum, Sofia 1113, Bulgaria | |
utb.scopus.affiliation | Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, třída Tomáše Bati 5678, Zlín, 76001, Czech Republic; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 25, Sofia, 1113, Bulgaria | |
utb.fulltext.projects | RP/CPS/2024-28/005 | |
utb.fulltext.projects | IGA/CPS/2023/005 | |
utb.fulltext.projects | IGA/CPS/2024/005 |