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Fucoidan- and ciprofloxacin-doped plasma-activated polymer coatings on biodegradable zinc: Hemocompatibility and drug release

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dc.title Fucoidan- and ciprofloxacin-doped plasma-activated polymer coatings on biodegradable zinc: Hemocompatibility and drug release en
dc.contributor.author Gorejová, Radka
dc.contributor.author Özaltin, Kadir
dc.contributor.author Šišoláková, Ivana
dc.contributor.author Kupková, Miriam
dc.contributor.author Sáha, Petr
dc.contributor.author Oriňáková, Renáta
dc.relation.ispartof ACS Omega
dc.identifier.issn 2470-1343 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2023
utb.relation.volume 8
utb.relation.issue 47
dc.citation.spage 44850
dc.citation.epage 44860
dc.type article
dc.language.iso en
dc.publisher American Chemical Society
dc.identifier.doi 10.1021/acsomega.3c06048
dc.relation.uri https://doi.org/10.1021/acsomega.3c06048
dc.relation.uri https://pubs.acs.org/doi/epdf/10.1021/acsomega.3c06048
dc.description.abstract Blood-contacting medical devices such as biodegradable metallic bone implant materials are expected to show excellent hemocompatibility both in vitro and in vivo. Different approaches are being studied and used to modify biomaterial surfaces for enhanced biocompatibility and hemocompatibility. However, the composition of degradable biomaterial must address several drawbacks at once. Iron-reinforced zinc material was used as a metallic substrate with improved mechanical properties when compared with those of pure zinc. Poly(lactic) acid (PLA) or polyethylenimine (PEI) was selected as a polymeric matrix for further doping with antibiotic ciprofloxacin (CPR) and marine-sourced polysaccharide fucoidan (FU), which are known for their antibacterial and potential anticoagulant properties, respectively. Radiofrequency air plasma was employed to induce metallic/polymer-coated surface activation before further modification with FU/CPR. Sample surface morphology and composition were studied and evaluated (contact angle measurements, AFM, SEM, and FT-IR) along with the hemolysis ratio and platelet adhesion test. Successful doping of the polymer layer by FU/CRP was confirmed. While PEI induced severe hemolysis over 12%, the PLA-coated samples exhibited even lower hemolysis (∼2%) than uncoated samples while the uncoated samples showed the lowest platelet adhesion. Moreover, gradual antibiotic release from PLA determined by the electrochemical methods using screen-printed carbon electrodes was observed after 24, 48, and 72 h, making the PLA-coated zinc-based material an attractive candidate for biodegradable material design. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1011796
utb.identifier.obdid 43885112
utb.identifier.scopus 2-s2.0-85179161068
utb.identifier.wok 001110608400001
utb.identifier.pubmed 38046307
utb.source j-scopus
dc.date.accessioned 2024-02-14T13:51:46Z
dc.date.available 2024-02-14T13:51:46Z
dc.description.sponsorship Development Agency; International Visegrad Fund, IVF, (22310096); Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT, (RP/CPS/2022/001, RP/CPS/2022/005); Agentúra na Podporu Výskumu a Vývoja, APVV, (APVV-20-0278, CZ.02.2.69/0.0/0.0/18_053/0017879)
dc.description.sponsorship International Visegrad Fund [APVV-20-0278]; Slovak Research and Development Agency [CZ.02.2.69/0.0/0.0/18_053/0017879]; Operational Program for Research, Development and Education; Ministry of Education, Youth and Sports of the Czech Republic [RP/CPS/2022/001]; DKRVO [22310096]; Visegrad grants from the International Visegrad Fund
dc.rights Attribution-NonCommercial-NoDerivs 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.access openAccess
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Gorejová, Radka
utb.contributor.internalauthor Özaltin, Kadir
utb.contributor.internalauthor Šišoláková, Ivana
utb.contributor.internalauthor Sáha, Petr
utb.contributor.internalauthor Oriňáková, Renáta
utb.fulltext.sponsorship This work was supported by the Slovak Research and Development Agency under the project APVV-20-0278, the Operational Program for Research, Development and Education within the framework of project no. CZ.02.2.69/0.0/0.0/18_053/0017879 entitled International mobility of UTB researchers in Zlín II, the Development Agency and the Ministry of Education, Youth and Sports of the Czech Republic (project no. DKRVO RP/CPS/2022/005 and DKRVO RP/CPS/2022/001), and Visegrad grants from the International Visegrad Fund (project no. 22310096).
utb.wos.affiliation [Gorejova, Radka; Sisolakova, Ivana; Orinakova, Renata] Pavol Jozef Safarik Univ Kosice, Fac Sci, Dept Phys Chem, Kosice 04154, Slovakia; [Gorejova, Radka; Ozaltin, Kadir; Sisolakova, Ivana; Saha, Petr; Orinakova, Renata] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Kupkova, Miriam] Slovak Acad Sci, Inst Mat Res, Kosice 04001, Slovakia
utb.scopus.affiliation Department of Physical Chemistry, Faculty of Science, Pavol Jozef Šafárik University in Košice, Moyzesova 11, Košice, 041 54, Slovakia; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, Zlín, 760 01, Czech Republic; Institute of Materials Research, Slovak Academy of Sciences, Watsonova 47, Košice, 040 01, Slovakia
utb.fulltext.projects APVV-20-0278
utb.fulltext.projects CZ.02.2.69/0.0/0.0/18_053/0017879
utb.fulltext.projects DKRVO RP/CPS/2022/005
utb.fulltext.projects DKRVO RP/CPS/2022/001
utb.fulltext.projects 22310096
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