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Biocompatibility of colloidal polypyrrole

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dc.title Biocompatibility of colloidal polypyrrole en
dc.contributor.author Káčerová, Simona
dc.contributor.author Víchová, Zdenka
dc.contributor.author Valášková, Kristýna
dc.contributor.author Vícha, Jan
dc.contributor.author Münster, Lukáš
dc.contributor.author Kašpárková, Věra
dc.contributor.author Vašíček, Ondřej
dc.contributor.author Humpolíček, Petr
dc.relation.ispartof Colloids and Surfaces B: Biointerfaces
dc.identifier.issn 0927-7765 Scopus Sources, Sherpa/RoMEO, JCR
dc.identifier.issn 1873-4367 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2023
utb.relation.volume 232
dc.type article
dc.language.iso en
dc.publisher Elsevier B.V.
dc.identifier.doi 10.1016/j.colsurfb.2023.113605
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0927776523004836
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0927776523004836/pdfft?md5=22f5482cfd4a69059bad0091e1876ff1&pid=1-s2.0-S0927776523004836-main.pdf
dc.subject polypyrrole en
dc.subject colloidal dispersion en
dc.subject conductive polymer en
dc.subject biomaterial en
dc.description.abstract The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or biosensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is ≤ 200 µg mL−1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 µg mL−1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1011766
utb.identifier.obdid 43884982
utb.identifier.scopus 2-s2.0-85175161602
utb.identifier.wok 001102656700001
utb.identifier.coden CSBBE
utb.source j-scopus
dc.date.accessioned 2024-02-02T10:29:26Z
dc.date.available 2024-02-02T10:29:26Z
dc.description.sponsorship DKRVO, (RP/CPS/2022/001, RP/CPS/2022/007); Tomas Bata University in Zlin, TBU, (IGA/CPS/2023/001); Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Grantová Agentura České Republiky, GA ČR, (23-07425S)
dc.description.sponsorship Czech Science Foundation [23-07425S]; Ministry of Education, Youth and Sports of the Czech Republic - DKRVO [RP/CPS/2022/001, RP/CPS/2022/007]; Internal Grants of TBU in Zlin [IGA/CPS/2023/001]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Káčerová, Simona
utb.contributor.internalauthor Víchová, Zdenka
utb.contributor.internalauthor Valášková, Kristýna
utb.contributor.internalauthor Vícha, Jan
utb.contributor.internalauthor Münster, Lukáš
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Humpolíček, Petr
utb.fulltext.sponsorship This work was supported by the Czech Science Foundation (23-07425S) and by the Ministry of Education, Youth and Sports of the Czech Republic – DKRVO (RP/CPS/2022/001) and (RP/CPS/2022/007). S.K. and K.V. also appreciate support of the Internal Grants of TBU in Zlín IGA/CPS/2023/001 funded from the resources of specific academic research.
utb.wos.affiliation [Kacerova, Simona; Vichova, Zdenka; Valaskova, Kristyna; Vicha, Jan; Munster, Lukas; Kasparkova, Vera] Tomas Bata Univ Zlin, Ctr Polymer Syst, Nam T G Masaryka 5678, Zlin 76001, Czech Republic; [Kasparkova, Vera; Humpolicek, Petr] Tomas Bata Univ Zlin, Fac Technol, Vavreckova 5669, Zlin 76001, Czech Republic; [Vasicek, Ondrej] Czech Acad Sci, Inst Biophys, Kralovopolska 135, Brno 61200, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlin, nám. T. G. Masaryka 5678, Zlin, 76001, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, Vavrečkova 5669, Zlin, 76001, Czech Republic; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, Brno, 61200, Czech Republic
utb.fulltext.projects 23-07425S
utb.fulltext.projects DKRVO (RP/CPS/2022/001)
utb.fulltext.projects DKRVO (RP/CPS/2022/007)
utb.fulltext.projects IGA/CPS/2023/001
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