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Polyaniline colloids stabilized with bioactive polysaccharides: Non-cytotoxic antibacterial materials

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dc.title Polyaniline colloids stabilized with bioactive polysaccharides: Non-cytotoxic antibacterial materials en
dc.contributor.author Kašpárková, Věra
dc.contributor.author Jasenská, Daniela
dc.contributor.author Capáková, Zdenka
dc.contributor.author Maráková, Nela
dc.contributor.author Stejskal, Jaroslav
dc.contributor.author Bober, Patrycja
dc.contributor.author Lehocký, Marián
dc.contributor.author Humpolíček, Petr
dc.relation.ispartof Carbohydrate Polymers
dc.identifier.issn 0144-8617 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2019
utb.relation.volume 219
dc.citation.spage 423
dc.citation.epage 430
dc.type article
dc.language.iso en
dc.publisher Elsevier Ltd
dc.identifier.doi 10.1016/j.carbpol.2019.05.038
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S0144861719305466
dc.subject Sodium hyaluronate en
dc.subject Chitosan en
dc.subject Colloid en
dc.subject Polyaniline en
dc.subject Antibacterial effect en
dc.subject Cytotoxicity en
dc.description.abstract Colloidal polyaniline dispersions stabilized with biocompatible polysaccharides, sodium hyaluronate and chitosan (both with two different molecular weights), were successfully formulated. The colloids were characterized by UV–vis spectra, particle-size distributions and morphology, as well as by their biological properties in terms of cytotoxicity and antibacterial activity. Colloids containing both chitosan and hyaluronate showed only mild cytotoxicities, which were mainly governed by the concentration of conducting polyaniline in the colloid. Antibacterial activity of the samples, however, depended both on the type of polysaccharide and the ratio between the stabilizer and polyaniline mass. The colloid synthetized using 0.2 M aniline hydrochloride, 0.1 M ammonium persulfate, and 1 wt.% sodium hyaluronate of molecular weight of 1.8–2.1 × 10 6 exhibited the highest antibacterial activity against both gram positive and gram negative bacteria. This formulation, therefore, allowed for the formation of potentially stimuli-responsive antibacterial colloidal particles with low cytotoxicity. © 2019 Elsevier Ltd en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1008739
utb.identifier.obdid 43880500
utb.identifier.scopus 2-s2.0-85065913755
utb.identifier.wok 000469334500045
utb.identifier.coden CAPOD
utb.source j-scopus
dc.date.accessioned 2019-08-13T10:17:02Z
dc.date.available 2019-08-13T10:17:02Z
dc.description.sponsorship Czech Science Foundation [1705095S]; Ministry of Education, Youth and Sports of the Czech Republic (NPU I) [LO1504]; Tomas Bata University [ZlinIGA/CPS/2019/004]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Kašpárková, Věra
utb.contributor.internalauthor Jasenská, Daniela
utb.contributor.internalauthor Capáková, Zdenka
utb.contributor.internalauthor Maráková, Nela
utb.contributor.internalauthor Lehocký, Marián
utb.contributor.internalauthor Humpolíček, Petr
utb.fulltext.sponsorship This work was supported by the Czech Science Foundation (17-05095S), and by the Ministry of Education, Youth and Sports of the Czech Republic (NPU I, LO1504). One of us (D.J.) also appreciates support of the internal grants of Tomas Bata University in ZlínIGA/CPS/ 2019/004 funded from the resources of specific academic research. Authors thank Ms. Daniela Veselá for technical support and Petr Ponížil for help with statistical evaluation.
utb.wos.affiliation [Kasparkova, Vera; Jasenska, Daniela; Capakova, Zdenka; Marakova, Nela; Lehocky, Marian; Humpolicek, Petr] Tomas Bata Univ Zlin, Ctr Polymer Syst, Zlin 76001, Czech Republic; [Kasparkova, Vera; Lehocky, Marian; Humpolicek, Petr] Tomas Bata Univ Zlin, Fac Technol, Zlin 76001, Czech Republic; [Stejskal, Jaroslav; Bober, Patrycja] Acad Sci Czech Republ, Inst Macromol Chem, Prague 16206 6, Czech Republic
utb.scopus.affiliation Centre of Polymer Systems, Tomas Bata University in Zlin, Zlin, 760 01, Czech Republic; Tomas Bata University in Zlin, Faculty of Technology, Zlin, 760 01, Czech Republic; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague 6162 06, Czech Republic
utb.fulltext.projects 17-05095S
utb.fulltext.projects LO1504
utb.fulltext.projects IGA/CPS/2019/004
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