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Calcium phosphate and calcium carbonate mineralization of bioinspired hydrogels based on β-chitin isolated from biomineral of the common cuttlefish (Sepia officinalis, L.)

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dc.title Calcium phosphate and calcium carbonate mineralization of bioinspired hydrogels based on β-chitin isolated from biomineral of the common cuttlefish (Sepia officinalis, L.) en
dc.contributor.author Čadež, Vida
dc.contributor.author Šegota, Suzana
dc.contributor.author Sondi, Ivan
dc.contributor.author Lyons, Daniel M.
dc.contributor.author Sáha, Petr
dc.contributor.author Saha, Nabanita
dc.contributor.author Sikirić, Maja Dutour
dc.relation.ispartof Journal of Polymer Research
dc.identifier.issn 1022-9760 Scopus Sources, Sherpa/RoMEO, JCR
dc.date.issued 2018
utb.relation.volume 25
utb.relation.issue 10
dc.type article
dc.language.iso en
dc.publisher Springer Netherlands
dc.identifier.doi 10.1007/s10965-018-1626-z
dc.relation.uri https://link.springer.com/article/10.1007/s10965-018-1626-z
dc.subject Cuttlebone en
dc.subject Chitin en
dc.subject AFM en
dc.subject Hydrogels en
dc.subject Mineralization en
dc.subject Mechanical properties en
dc.description.abstract Chitin, a bioactive, antibacterial and biodegradable polymer is commonly utilized by diverse marine organisms as the main scaffold material during biomineralization. Due to its properties, chitin is also of interest as a component of organo-inorganic composites for diverse biomedical applications. In this study, chitinous fibers isolated from the cuttlebone of the common cuttlefish (Sepia officinalis, L.) are characterized and evaluated for use as an integral part of mineralized hydrogels for biomedical applications. Since marine organisms use calcium carbonates (CaCO3), while vertebrates use calcium phosphates (CaP) as the main inorganic hard tissue components, and both minerals are used in hard tissue engineering, they were compared to determine which composite is potentially a better biomaterial. Hydrogel mineralization was conducted by subsequent dipping into cationic and anionic reactant solutions, resulting in the formation of a CaCO3 or CaP coating that penetrated into the hydrogel. Obtained composites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), rheology, swelling tests and simple compression. The results indicate that β-chitin can be used for the preparation of moldable hydrogels that are easily mineralized. Mineralized hydrogels have higher elasticity than non-mineralized ones while swelling is better if the extent of mineralization is lower. Further optimization of the hydrogels composition could improve their stress response and Young’s modulus, where the current hydrogel with a higher extent of CaP mineralization excels in comparison to all other investigated composites. © 2018, Springer Nature B.V. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1008220
utb.identifier.obdid 43879679
utb.identifier.scopus 2-s2.0-85053859128
utb.identifier.wok 000445692600002
utb.identifier.coden JPORE
utb.source j-scopus
dc.date.accessioned 2018-10-18T10:31:45Z
dc.date.available 2018-10-18T10:31:45Z
dc.description.sponsorship Croatian Science Foundation [IP-2013-11-5055]; Ministry of Education, Youth and Sports of the Czech Republic, Program NPU I [LO1504]; COST Action [MP1301]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Sáha, Petr
utb.contributor.internalauthor Saha, Nabanita
utb.wos.affiliation [Cadez, Vida; Segota, Suzana; Sikiric, Maja Dutour] Rudjer Boskovic Inst, Div Phys Chem, Lab Biocolloids & Surface Chem, Zagreb 10000, Croatia; [Sondi, Ivan] Fac Min Geol & Petr Engn, Pierrotijeva 6, Zagreb 10000, Croatia; [Lyons, Daniel M.] Rudjer Boskovic Inst, Ctr Marine Res, Lab Marine Nanotechnol & Biotechnol, Giordano Paliaga 5, Rovinj 52210, Croatia; [Saha, Petr; Saha, Nabanita] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Tr Tomase Bati 5678, Zlin 76001, Czech Republic
utb.scopus.affiliation Laboratory for Biocolloids and Surface Chemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Zagreb, 10000, Croatia; Faculty of Mining, Geology and Petroleum Engineering, Pierrotijeva 6, Zagreb, 10000, Croatia; Laboratory for Marine Nanotechnology and Biotechnology, Center for Marine Research, Ruđer Bošković Institute, Giordano Paliaga 5, Rovinj, 52210, Croatia; Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, tř. Tomáše Bati 5678, Zlín, 760 01, Czech Republic
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