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Green synthesis of silver nanoparticles and biopolymer nanocomposites: a comparative study on physico-chemical, antimicrobial and anticancer activity

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dc.title Green synthesis of silver nanoparticles and biopolymer nanocomposites: a comparative study on physico-chemical, antimicrobial and anticancer activity en
dc.contributor.author Palem, Ramasubba Reidy
dc.contributor.author Ganesh, Shimoga D.
dc.contributor.author Kroneková, Zuzana
dc.contributor.author Sláviková, Monika
dc.contributor.author Saha, Nabanita
dc.contributor.author Sáha, Petr
dc.relation.ispartof Bulletin of Materials Science
dc.identifier.issn 0250-4707 OCLC, Ulrich, Sherpa/RoMEO, JCR
dc.date.issued 2018
utb.relation.volume 41
utb.relation.issue 2
dc.type article
dc.language.iso en
dc.publisher Indian Academy of Sciences
dc.identifier.doi 10.1007/s12034-018-1567-5
dc.relation.uri https://link.springer.com/article/10.1007/s12034-018-1567-5
dc.subject Biogenic silver nanoparticles en
dc.subject biopolymer nanocomposites en
dc.subject nanoparticles stability en
dc.subject antimicrobial activity en
dc.subject anticancer activity en
dc.description.abstract The current report was intended towards comparative study of green-synthesized biogenic Rhubarb silver nanoparticles (RS-AgNPs) and chitosan crosslinked silver nanocomposites (CSHD-AgNCs). The physico-chemical characterization was done by UV-visible, FTIR, scanning electron microscopy (SUM), transmission electron microscopy (TEM), TGA, XRD and zeta potential(zeta). The analysis and spectroscopic characterization was done by SEM and TEM and their results reveal that the nanoparticles are spherical in shape, with average size ranges from 5 to 50 nm, and was gathered by face centered cubic (FCC) structure throughout the polymer matrix and stable without any protecting or capping reagents over 450 days. The antimicrobial property of RS-AgNPs and CSHD-AgNCs (zeta = +29.6 and +32.8 mV) was evaluated against E. coli and S. aureus and showed an effective inhibitory property. The RS-AgNPs and CSHD-AgNCs were assessed for their anticancer activity against HeLa cell line by MTT method, and it reveals a dose response activity, time and cell line-dependent cytotoxicity. Based on the results obtained, the RS-AgNPs exhibited higher toxicity over CSHD-AgNCs after 24 h incubation of HeLa cells with different concentrations and is negligible for the aqueous Rhubarb extract. It was concluded that the changes in anticancer activity towards HeLa cells due to biological activity of silver nanoparticles depend on their method of biosynthesis and their physico-chemical nature. en
utb.faculty University Institute
dc.identifier.uri http://hdl.handle.net/10563/1007928
utb.identifier.wok 000430795900020
utb.source j-wok
dc.date.accessioned 2018-05-18T15:12:09Z
dc.date.available 2018-05-18T15:12:09Z
dc.description.sponsorship Ministry of Education, Youth and Sports of the Czech Republic-NPU Program I [LO1504]; Slovak Grant Agency VEGA [2/0124/18]
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Palem, Ramasubba Reidy
utb.contributor.internalauthor Ganesh, Shimoga D.
utb.contributor.internalauthor Saha, Nabanita
utb.contributor.internalauthor Sáha, Petr
utb.wos.affiliation [Palem, Ramasubba Reidy; Ganesh, Shimoga D.; Saha, Nabanita; Saha, Petr] Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Tr T Bati 5678, Zlin 76001, Czech Republic; [Kronekova, Zuzana] Slovak Acad Sci, Polymer Inst, Dept Biomat Res, Dubrayska Cesta 9, Bratislava 84541, Slovakia; [Slavikova, Monika] Slovak Acad Sci, Biomed Ctr, Inst Virol, Dubrayska Cesta 9, Bratislava 84505, Slovakia
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