TBU Publications
Repository of TBU Publications

Risk profile analysis and complications after surgery for autoimmune thyroid disease

DSpace Repository

Show simple item record


dc.title Risk profile analysis and complications after surgery for autoimmune thyroid disease en
dc.contributor.author Thomusch, Oliver
dc.contributor.author Sekulla, C.
dc.contributor.author Billmann, F.
dc.contributor.author Seifert, G.
dc.contributor.author Dralle, H.
dc.contributor.author Lorenz, K.
dc.contributor.author Vorländer, C.
dc.contributor.author Dralle, H.
dc.contributor.author Freitag, M.
dc.contributor.author Jähne, J.
dc.contributor.author Steinmüller, T.
dc.contributor.author Trupka, A.
dc.contributor.author Steinert, F.
dc.contributor.author Schabram, J.
dc.contributor.author Heinzmann, B.
dc.contributor.author Lang, H.
dc.contributor.author Cotte, J.
dc.contributor.author Hoffmann, T.F.
dc.contributor.author Dette, K.
dc.contributor.author Gellert, K.
dc.contributor.author Henne-Bruns, D.
dc.contributor.author Boese-Landgraf, J.
dc.contributor.author Simon Evangelisches, D.
dc.contributor.author Kube, R.
dc.contributor.author Lorenz, E.P.M.
dc.contributor.author Pross, M.
dc.contributor.author Hartel, M.
dc.contributor.author Thomschke, D.
dc.contributor.author Pistorius, G.
dc.contributor.author Hopt, U.T.
dc.contributor.author Franke, C.
dc.contributor.author Rose, U.
dc.contributor.author Steuer, W.
dc.contributor.author Schwenk, W.
dc.contributor.author Ebert, K.-H.
dc.contributor.author Kelm, C.
dc.contributor.author Witzigmann, H.
dc.contributor.author Rampf, W.
dc.contributor.author Ridwelski, K.
dc.contributor.author Knoefel, W.T.
dc.contributor.author Bechstein, W.O.
dc.contributor.author Grothe, D.
dc.contributor.author Anthuber, M.
dc.contributor.author Mirow, L.
dc.contributor.author Probst, W.
dc.contributor.author Thews, A.
dc.contributor.author Fleck, U.
dc.contributor.author Kärgel, W.
dc.contributor.author Schimmelpenning, H.
dc.contributor.author Fielitz, J.
dc.contributor.author Rose, U.
dc.contributor.author Schöffauer, T.
dc.contributor.author Asperger, W.
dc.contributor.author Zaage, J.
dc.contributor.author Dorn, H.-U.
dc.contributor.author Weitz, J.
dc.contributor.author Neubauer, M.
dc.contributor.author Klar, E.
dc.contributor.author Lautermann, J.
dc.contributor.author Senkal, M.
dc.contributor.author Lippert, H.
dc.contributor.author Lück, R.
dc.contributor.author Ziesche, M.
dc.contributor.author Kröll, K.-P.
dc.contributor.author Skrobisz, J.
dc.contributor.author Lorenc, Z.
dc.contributor.author Dudešek, Bohumil
dc.contributor.author Smutny, S.
dc.contributor.author Brauckhoff, M.
dc.contributor.author Längle, F.
dc.contributor.author Wenzl, E.
dc.contributor.author the Prospective Evaluation Study of Thyroid Surgery (PETS 2) Study Group
dc.relation.ispartof British Journal of Surgery
dc.identifier.issn 0007-1323 OCLC, Ulrich, Sherpa/RoMEO, JCR
dc.date.issued 2018
utb.relation.volume 105
utb.relation.issue 6
dc.citation.spage 677
dc.citation.epage 685
dc.type article
dc.language.iso en
dc.publisher John Wiley and Sons Ltd.
dc.identifier.doi 10.1002/bjs.10770
dc.relation.uri https://onlinelibrary.wiley.com/doi/abs/10.1002/bjs.10770
dc.description.abstract Background: Surgical approaches to autoimmune thyroid disease are currently hampered by concerns over postoperative complications. Risk profiles and incidences of postoperative complications have not been investigated systematically, and studies with sufficient power to show valid data have not been performed. Methods: A prospective multicentre European study was conducted between July 2010 and December 2012. Questionnaires were used to collect data prospectively on patients who had surgery for autoimmune thyroid disease and the findings were compared with those of patients undergoing surgery for multinodular goitre. Logistic regression analysis was used to evaluate risk factors for thyroid surgery-specific complications, transient and permanent recurrent laryngeal nerve (RLN) palsy and hypoparathyroidism. Results: Data were available for 22 011 patients, of whom 18 955 were eligible for analysis (2488 who had surgery for autoimmune thyroid disease and 16 467 for multinodular goitre). Surgery for multinodular goitre and that for autoimmune thyroid disease did not differ significantly with regard to general complications. With regard to thyroid surgery-specific complications, the rate of temporary and permanent vocal cord palsy ranged from 2·7 to 6·7 per cent (P = 0·623) and from 0·0 to 1·4 per cent (P = 0·600) respectively, whereas the range for temporary and permanent hypoparathyroidism was 12·9 to 20·0 per cent (P < 0·001) and 0·0 to 7·0 per cent (P < 0·001) respectively. In logistic regression analysis of transient and permanent vocal cord palsy, autoimmune thyroid disease was not an independent risk factor. Autoimmune thyroid disease, extent of thyroid resection, number of identified parathyroid glands and no autotransplantation were identified as independent risk factors for both transient and permanent hypoparathyroidism. Conclusion: Surgery for autoimmune thyroid disease is safe in comparison with surgery for multinodular goitre in terms of general complications and RLN palsy. To avoid the increased risk of postoperative hypoparathyroidism, special attention needs to be paid to the parathyroid glands. © 2018 BJS Society Ltd Published by John Wiley & Sons Ltd en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1007889
utb.identifier.obdid 43878348
utb.identifier.scopus 2-s2.0-85044443801
utb.identifier.pubmed 29579336
utb.identifier.coden BJSUA
utb.source j-scopus
dc.date.accessioned 2018-05-18T15:12:04Z
dc.date.available 2018-05-18T15:12:04Z
dc.description.sponsorship Stiftelserna Wilhelm och Martina Lundgrens
utb.contributor.internalauthor Dudešek, Bohumil
utb.fulltext.affiliation O. Thomusch1 , C. Sekulla2, F. Billmann3, G. Seifert1, H. Dralle2 and K. Lorenz2, on behalf of the Prospective Evaluation Study of Thyroid Surgery (PETS 2) Study Group 1 Department of General and Visceral Surgery, Albert Ludwig University of Freiburg, Freiburg, 2 Department of General, Vascular and Visceral Surgery, Martin Luther University of Halle-Wittenberg, Halle an der Saale, and 3 Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany Correspondence to: Professor O. Thomusch, Department of General and Visceral Surgery, Albert Ludwig University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany (e-mail: oliver.thomusch@uniklinik-freiburg.de)
utb.fulltext.dates Paper accepted 25 October 2017
utb.fulltext.references 1 Tunbridge WMG, Evered DC, Hall R, Appleton D, Brewis M, Clark F et al. The spectrum of thyroid disease in a community: the Wickham survey. Clin Endocrinol (Oxf) 1977; 7: 841–493. 2 Stalberg P, Svensson A, Hessman O, Akerström G, Hellman P. Surgical treatment of Graves’ disease: evidence-based approach. World J Surg 2008; 32: 1269–1277. 3 Thomusch O, Machens A, Sekulla C, Ukkat J, Lippert H, Gastinger I et al. Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: prospective multicenter study in Germany. World J Surg 2000; 24: 1335–1341. 4 Serpell JW, Lee JC, Yeung MJ, Grodski S, Johnson W, Bailey M. Differential recurrent laryngeal nerve palsy rates after thyroidectomy. Surgery 2014; 156: 1157–1166. 5 Hermann M, Alk G, Roka R, Glaser K, Freissmuth M. Laryngeal recurrent nerve injury in surgery for benign thyroid diseases: effect of nerve dissection and impact of individual surgeon in more than 27 000 nerves at risk. Ann Surg 2002; 235: 261–268. 6 Snyder SK, Sigmond BR, Lairmore TC, Govednik-Horny CM, Janicek AK, Jupiter DC. The long-term impact of routine intraoperative nerve monitoring during thyroid and parathyroid surgery. Surgery 2013; 154: 704–711. 7 Chiang FY, Wang LF, Huang YF, Lee KW, Kuo WR. Recurrent laryngeal nerve palsy after thyroidectomy with routine identification of the recurrent laryngeal nerve. Surgery 2005; 137: 342–347. 8 Mok VM, Oltmann SC, Chen H, Sippel RS, Schneider DF. Identifying predictors of a difficult thyroidectomy. J Surg Res 2014; 190: 157–163. 9 McManus C, Luo J, Sippel R, Chen H. Is thyroidectomy in patients with Hashimoto thyroiditis more risky? J Surg Res 2012; 178: 529–532. 10 Shimizu K, Nakajima Y, Kitagawa W, Akasu H, Takatsu K, Ishii R et al. Surgical therapy in Hashimioto’s thyroiditis. J Nippon Med Sch 2003; 70: 34–39. 11 Shih ML, Lee JA, Hsieh CB, Yu JC, Liu HD, Kebebew E et al. Thyroidectomy for Hashimoto’s thyroiditis: complications and associated cancers. Thyroid 2008; 18: 729–734. 12 Promberger R, Hermann M, Pallikunnel SJ, Seemann R, Meusel M, Ott J. Quality of life after thyroid surgery in women with benign euthyroid goiter: influencing factors including Hashimoto’s thyroiditis. Am J Surg 2014; 207: 974–979. 13 McManus C, Luo J, Sippel R, Chen H. Should patients with symptomatic Hashimoto thyroiditis pursue surgery? J Surg Res 2011; 170: 52–55. 14 Feroci F, Rettori M, Borrelli A, Coppola A, Castagnoli A, Perigli G et al. A systematic review and meta-analysis of total thyroidectomy versus bilateral subtotal thyroidectomy for Graves’ disease. Surgery 2014; 155: 529–540. 15 Enomoto K, Uchino S, Watanabe S, Enomoto Y, Noguchi S. Recurrent laryngeal nerve palsy during surgery for benign thyroid diseases: risk factor and outcome analysis. Surgery 2014; 155: 522–528. 16 Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid 2016; 26: 1343–1421. 17 Sugino K, Ito K, Nagahama M, Kitagawa W, Shibuya H, Ito K. Surgical management of Graves’ disease – 10-year prospective trial at a single institution. Endocr J 2008; 55: 161–167. 18 Loh KC, Greenspan FS, Dong F, Miller TR, Yeo PP. Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 1999; 84: 458–463.
utb.fulltext.sponsorship O.T and C.S. contributed equally to this publication. The study received financial support from the Wilhelm Roux Foundation of Martin Luther University of HalleWittenberg. Disclosure: The authors declare no conflict of interest.
utb.scopus.affiliation Department of General and Visceral Surgery, Albert Ludwig University of Freiburg, Freiburg, Germany; Department of General, Vascular and Visceral Surgery, Martin Luther University of Halle-Wittenberg, Halle an der Saale, Germany; Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany; Department of Endocrine Surgery, Bürgerhospital Frankfurt am Main, Germany; Department of General, Visceral and Vascular Surgery, University Hospital Halle/Saale, Germany; Department of Surgery, Hospital St Josef-Stift, Dresden, Germany; Department of Surgery, Henriettenstiftung, Hannover, Germany; Department of General Surgery, DRK Hospitals Berlin, Germany; Department of Surgery, Hospital Starnberg, Germany; Department of General and Visceral Surgery, HELIOS Hospital Schkeuditz, Germany; Department of General and Visceral Surgery, St Josef's Hospital Giessen, Germany; Department of Surgery, Hospital St Marienstift Magdeburg, Germany; Department of General and Visceral Surgery, University Hospital of Mainz, Germany; Department of Thyroid Surgery, Eichsfeld Hospital, Reifenstein, Italy; Department of Surgery, Maria Theresia Hospital, Munich, Germany; Department of Surgery, Vivantes Wenckebach-Hospital, Berlin, Germany; Department of General and Visceral Surgery, Sana Hospital Lichtenberg, Berlin-, Lichtenberg, Germany; Department of General, Visceral and Transplantation Surgery, University Hospital of Ulm, Germany; Department of General and Visceral Surgery, Hospital Chemnitz, Germany; Department of General and Visceral Surgery, Bethesda Johanniter Hospital Duisburg, Germany; Department of Surgery, Carl-Thiem-Hospital Cottbus, Germany; Department of Surgery, St Hedwig Hospital Berlin, Germany; Department of Surgery, DRK Hospital Berlin Köpenick, Berlin, Germany; Department of Surgery, Hospital Dortmund, Germany; Department of General and Visceral Surgery, Hospital Kulmbach, Germany; Department of General and Visceral and Thoracic Surgery, Hospital Sozialstiftung Bamberg, Germany; Department of General and Visceral Surgery, University Hospital of Freiburg, Germany; Department of Surgery, Sana Hospital Benrath, Düsseldorf, Germany; Department of Surgery, Diakonie Hospital Halle, Germany; Department of Visceral Surgery, Westpfalz Hospital, Kaiserslautern, Germany; Department of General and Visceral Surgery, Asklepios Hospital Altona, Hamburg, Germany; Section of Surgery, St Martinus Hospital Olpe, Katholische Hospitalgesellschaft Südwestfalen, Olpe, Germany; Department of General and Visceral Surgery, Hospital Lüdenscheid, Germany; Department of General and Visceral Surgery, Städtisches Hospital Dresden Friedrichstadt, Dresden, Germany; Department of Surgery, Hospital 14 Nothelfer, Weingarten, Germany; Department of General and Visceral Surgery, Hospital Magdeburg, Germany; Department of General and Visceral Surgery, University Hospital of Düsseldorf, Germany; Department of General and Visceral Surgery, University Hospital of Universitätsklinikum Frankfurt am Main, Germany; Department of General and Visceral Surgery, Christliches Hospital Melle, Germany; Department of General, Visceral and Transplantation Surgery, Hospital Augsburg, Germany; Department of General and Visceral Surgery, Landkreis Mittweida Hospital, Mittweida, Germany; Department of General and Visceral Surgery, Ammerland Hospital, Westerstede, Germany; Department of Surgery, Hospital Schönebeck, Germany; Department of General and Visceral Surgery, DRK Hospital Luckenwalde, Germany; Klinik für Allgemein- und Visceralchirurgie, Klinikum Niederlausitz, Senftenberg, Germany; Department of General and Visceral Surgery, Hospital Neustadt, Germany; Department of Surgery, Paracelsus Hospital Reichenbach, Germany; Department of General, Visceral and Vascular Surgery, Hospital Martha Maria Halle Dölau, Halle/Saale, Germany; Department of Surgery, Oder Spree Hospital, Beeskow, Germany; Department of General and Visceral Surgery, Hospital St Elisabeth and St Barbara, Halle/Saale, Germany; Department of General Surgery, Hospital Bergmannstrost, Halle/Saale, Germany; Department of General and Visceral Surgery, Hospital Mittleres Erzgebirge Zschopau, Germany; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany; Department of Surgery, Hospital Freiberg, Germany; Department of General, Thoracic, Vascular and Transplantation Surgery, University Hospital of Rostock, Germany; Department of Ear, Nose and Throat Surgery, Hospital Martha Maria Halle-Dölau, Halle/Saale, Germany; Department of General and Visceral Surgery, Marien Hospital Witten, Germany; Department of General, Visceral and Vascular Surgery, University Hospital of Otto von Guericke University, Magdeburg, Germany; Department of General and Visceral Surgery, Sana Hospital Hameln-Pyrmont, Hameln, Germany; Department of General and Visceral Surgery, Suedharz Hospital Nordhausen, Germany; Department of General and Visceral Surgery, Hochwaldkrankenhaus, Bad Nauheim, Germany; Oddział Chirurgii Ogólnej, Szpital Wojewódzki w Poznaniu, Poznań, Poland; Specjalistyczny Nr 5 im. św. Barbary, Wojewódzki Szpital, Sosnowiec, Germany; Tomáš Bat'a University, Zlín, Czech Republic; Department of Surgery, Oblastni nemocnice Pribram, Germany; Department of Surgery, University of Bergen Haukeland University Hospital, Bergen, Norway; Department of Surgery, Hospital Vienna Neustadt, Austria; Department of General and Thoracic Surgery, Landeskrankenhaus Feldkirch, Germany
utb.fulltext.projects -
Find Full text

Files in this item

Show simple item record