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Phase II Drug Metabolism

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dc.title Phase II Drug Metabolism en
dc.contributor.author Jančová, Petra
dc.contributor.author Šiller, Michal
dc.relation.ispartof Topics on Drug Metabolism
dc.identifier.isbn 978-953-51-0099-7
dc.date.issued 2012
utb.event.state-en Croatia
utb.event.state-cs Chorvatsko
dc.type bookPart
dc.language.iso en
dc.publisher InTech
dc.identifier.doi 10.5772/1180
dc.relation.uri http://www.intechopen.com/books/topics-on-drug-metabolism/phase-ii-drug-metabolism
dc.subject phase II biotransformation en
dc.subject glucuronidation en
dc.subject sulfoconjugation en
dc.subject glutathione S-conjugation en
dc.subject acetylation en
dc.subject methylation en
dc.subject amino acid conjugation en
dc.description.abstract All organisms are constantly and unavoidably exposed to xenobiotics including both man–made and natural chemicals such as drugs, plant alkaloids, microorganism toxins, pollutants, pesticides, and other industrial chemicals. Formally, biotransformation of xenobiotics as well as endogenous compounds is subdivided into phase I and phase II reactions. This chapter focuses on phase II biotransformation reactions (also called ´conjugation reactions´) which generally serve as a detoxifying step in metabolism of drugs and other xenobiotics as well as endogenous substrates. On the other hand, these conjugations also play an essential role in the toxicity of many chemicals due to the metabolic formation of toxic metabolites such as reactive electrophiles. Gene polymorphism of biotransformation enzymes may often play a role in various pathophysiological processes. Conjugation reactions usually involve metabolite activation by a high–energy intermediate and have been classified into two general types: type I (e.g., glucuronidation and sulfonation), in which an activated conjugating agent combines with substrate to yield the conjugated product, and type II (e.g., amino acid conjugation), in which the substrate is activated and then combined with an amino acid to yield a conjugated product. In this chapter, we will concentrate on the most important conjugation reactions, namely glucuronide conjugation, sulfoconjugation, acetylation, amino acid conjugation, glutathione conjugation and methylation. en
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1005966
utb.identifier.rivid RIV/70883521:28110/12:43868798!RIV13-MSM-28110___
utb.identifier.obdid 43868981
utb.identifier.wok 000378144800003
utb.source c-riv
dc.date.accessioned 2016-04-28T10:37:28Z
dc.date.available 2016-04-28T10:37:28Z
dc.description.sponsorship P(ED0030/01/01), V
dc.format.extent 294
dc.rights Attribution 3.0 International
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.rights.access openAccess
utb.contributor.internalauthor Jančová, Petra
riv.obor CE
utb.fulltext.affiliation Petra Jančová1 and Michal Šiller2 1Department of Environmental Protection Engineering, Faculty of Technology, Tomas Bata University, Zlin, 2Department of Pharmacology and Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
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Attribution 3.0 International Except where otherwise noted, this item's license is described as Attribution 3.0 International