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Optimization of biodegradable polymeric submicroparticles preparation

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dc.title Optimization of biodegradable polymeric submicroparticles preparation en
dc.contributor.author Stloukal, Petr
dc.contributor.author Koutný, Marek
dc.contributor.author Sedlařík, Vladimír
dc.contributor.author Kucharczyk, Pavel
dc.relation.ispartof Recent Researches in Geography, Geology, Energy, Environment and Biomedicine - Proc. of the 4th WSEAS Int. Conf. on EMESEG'11, 2nd Int. Conf. on WORLD-GEO'11, 5th Int. Conf. on EDEB'11
dc.identifier.isbn 9781618040220
dc.date.issued 2011
dc.citation.spage 294
dc.citation.epage 299
dc.event.title 4th WSEAS International Conference on Engineering Mechanics, Structures, Engineering Geology, EMESEG'11, 2nd International Conference on Geography and Geology 2011, WORLD-GEO'11, 5th International Conference on EDEB'11
dc.event.location Corfu Island
utb.event.state-en Greece
utb.event.state-cs Řecko
dc.event.sdate 2011-07-14
dc.event.edate 2011-07-16
dc.type conferenceObject
dc.language.iso en
dc.relation.uri http://www.wseas.us/e-library/conferences/2011/Corfu/GEMESED/GEMESED-52.pdf
dc.subject Biodegradable copolymer en
dc.subject Gelatin en
dc.subject Microparticles en
dc.subject Nonionic surfactant en
dc.subject Oil-in-water (O/W) emulsion solvent evaporation method en
dc.subject Poly(lactide acid) en
dc.description.abstract The influence of various surfactants and their combinations on the particle diameter and particles size distribution during their preparation from biodegradable poly(lactide acid) by the method of emulsification and solvent evaporation at reduced pressure was investigated. The attention was focused on the possibility to control the size of resultant particles by hydrophilic-lipophilic balance parameter (HLB), which is a characteristic of nonionic surfactants. First, nonionic surfactants were combined to obtain various HLB values of the system and then combinations with the biodegradable surface active polymer Gelatin A were assayed. Gelatin A proved to be a suitable emulsion stabilizer in the process of PLA submicroparticles preparation and it was found that to achieve PLA submicroparticles with the lowest diameter and narrow distribution HLB of the system has to be set up under about 16. For combinations of gelatin A and another nonionic surfactant the reduction of the aggregate HLB value of the system could better be achieved with an addition of a surfactant having HLB closer to the optimum like Tween 20 or Tween 85. en
utb.faculty University Institute
utb.faculty Faculty of Technology
dc.identifier.uri http://hdl.handle.net/10563/1004727
utb.identifier.obdid 43866433
utb.identifier.scopus 2-s2.0-83655190734
utb.source d-scopus
dc.date.accessioned 2015-06-04T12:55:07Z
dc.date.available 2015-06-04T12:55:07Z
utb.ou Centre of Polymer Systems
utb.contributor.internalauthor Stloukal, Petr
utb.contributor.internalauthor Koutný, Marek
utb.contributor.internalauthor Sedlařík, Vladimír
utb.contributor.internalauthor Kucharczyk, Pavel
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