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The prevalence of decreased glomerular filtration rate in patients with monoclonal gammopathy of undetermined significance

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dc.title The prevalence of decreased glomerular filtration rate in patients with monoclonal gammopathy of undetermined significance en
dc.contributor.author Šálek, Tomáš
dc.contributor.author Moravčíková, Dagmar
dc.contributor.author Humpolíček, Petr
dc.contributor.author Tichý, Miloš
dc.contributor.author Palička, Vladimír
dc.relation.ispartof Klinická biochemie a metabolismus
dc.identifier.issn 1210-7921 OCLC, Ulrich, Sherpa/RoMEO, JCR
dc.date.issued 2013
utb.relation.volume 21
utb.relation.issue 1
dc.citation.spage 25
dc.citation.epage 29
dc.type article
dc.language.iso en
dc.publisher Česká lékařská společnost Jana Evangelisty Purkyně (ČLS JEP) cs
dc.relation.uri http://www.cskb.cz/res/file/KBM-pdf/2013/2013-1/abstrakta/Ab-KBM-1-2013-Salek-25.pdf
dc.subject Chronic renal failure en
dc.subject Free light chains en
dc.subject Glomerular filtration rate en
dc.subject Monoclonal gammopathy en
dc.description.abstract Background: Renal function is more frequently decreased in patients with monoclonal gammopathy. 10 % of patients with multiple myeloma present with acute renal failure and renal function is included in CRAB criteria for the diagnosis of multiple myeloma. Aim: The aim of this study is to determine the prevalence of chronic renal failure (CRF), defined as a glomerular filtration rate (GFR) below 1.0 ml/s/1.73m2, in 101 patients with monoclonal gammopathy of undetermined significance (MGUS). Design: retrospective study Material and methods: We compared GFR estimates from serum creatinine (MDRD GFR) and serum cystatin C (CysC GFR) and looked at the correlation between free light chains (FLC) concentration and renal markers. We performed serum protein electrophoresis (SPE) with quantification of monoclonal intact immunoglobulin (MIg) and measured serum creatinine, cystatin C, Κ and Λ FLC and β2microglobulin in all patients. Results: We found CRF in 38.6% patients using estimation from serum cystatin C and 34.6 % using estimation from serum creatinine. B2microglobulin has the highest number of significant correlations; cystatin C (0.90), CysC GFR (-0.69), creatinine (0.70), MDRD GFR (-0.60), MIg concentration (0.24), Κ FLC (0.22) Λ FLC (0.34) and age (0.40). The best correlation results may be explained by the fact that β2microglobulin reflects both malignant cells burden and renal function. Conclusions: We found CRF in 38.6 % MGUS patients using estimation from serum cystatin C and in 34.6 % using estimation from serum creatinine. The class of monoclonal immunoglobulin may influence results of glomerular filtration estimated from cystatin C but it does not influence GFR estimated from creatinine. Diabetic patients had not significantly lower GFR than patients without diabetes mellitus. © Ceská lékarská spolecnost Jana Evangelisty Purkyne, Praha 2013. en
utb.faculty Faculty of Humanities
dc.identifier.uri http://hdl.handle.net/10563/1003425
utb.identifier.obdid 43869919
utb.identifier.scopus 2-s2.0-84880518295
utb.identifier.coden KBMEF
utb.source j-scopus
dc.date.accessioned 2013-08-02T09:10:18Z
dc.date.available 2013-08-02T09:10:18Z
utb.contributor.internalauthor Moravčíková, Dagmar
utb.contributor.internalauthor Humpolíček, Petr
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